Methenamine hippurate

Base Information

• Chemical Name: Methenamine hippurate
• CAS No.: 5714-73-8
• Molecular Formula: C9H9NO3.C6H12N4
• Molecular Weight: 319.36 .
• Hs Code.: DERIVATION
• European Community (EC) Number: 227-206-5
• UNII: M329791L57
• DSSTox Substance ID: DTXSID10972603
• Wikidata: Q27283414
• NCI Thesaurus Code: C47610
• RXCUI: 29652
• ChEMBL ID: CHEMBL1201104
• Mol file: 5714-73-8.mol

Synonyms:hexamine hippurate;Hip-Rex;Hiprex;methenamine hippurate;Urex;Urotractan

Chemical Property of Methenamine hippurate

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 2.06E-09mmHg at 25°C
• Melting Point: 89-95oC
• Boiling Point: 464.1°Cat760mmHg
• Flash Point: 234.5°C
• PSA: 79.36000
• Density: g/cm³
• LogP: -0.37630
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 319.16443955
• Heavy Atom Count: 23
• Complexity: 282

Purity/Quality:

99% ^*data from raw suppliers

MethenamineHippurate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): UN NO.
• Hazard Codes: UN NO.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1N2CN3CN1CN(C2)C3.C1=CC=C(C=C1)C(=O)NCC(=O)O
• Recent ClinicalTrials: Urinary Track Infection Prevention After Urogynecological Surgery
• Recent EU Clinical Trials: The effect of methenamine hippurate to reduce antibiotic prescribing due to new episodes of urinary tract infections (UTI) in elderly women with recurrent UTI – a triple-blinded,randomized placebo-controlled phase IV study
• Description: Methenamine hippurate is a broad-spectrum urinary antiseptic agent. Under acidic conditions, methenamine hippurate is hydrolyzed to formaldehyde and ammonia, which exerts an antibacterial effect. It is effective against a wide range of bacteria but lacks activity against Proteus and other bacteria that increase urine alkalinity. Formulations containing methenamine hippurate have been used to treat urinary tract infections.
• Therapeutic Function: Antibacterial (urinary)
• Clinical Use: Antibacterial agent
• Drug interactions: Potentially hazardous interactions with other drugs Antibacterials: increased risk of crystalluria with sulphonamides. Diuretics: effects antagonised by acetazolamide.