8-(aminomethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Base Information

• Chemical Name: 8-(aminomethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide
• CAS No.: 1351945-12-4
• Molecular Formula: C₂₅H₂₀F₃N₃O₂
• Molecular Weight: 451.448
• Mol file: 1351945-12-4.mol

Synonyms:8-(aminomethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Chemical Property of 8-(aminomethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(aminomethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

There total 10 articles about 8-(aminomethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H18F3N5O2 → 8-(aminomethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide (1351945-12-4)

Guidance literature:

With hydrogen; pyrographite; palladium; In 1,4-dioxane; at 20 ℃; for 16h; under 760.051 Torr;

DOI:10.1021/ml200252b

Reference yield:

8-chloro-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide (1351945-28-2) → 8-(aminomethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide (1351945-12-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; cesium fluoride / 1,4-dioxane / 16 h / 50 °C / Inert atmosphere

2.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 20 °C

3.1: sodium periodate / water; acetone / 20 °C

4.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 0.5 h / Inert atmosphere

4.2: 0.5 h

5.1: 1,8-diazabicyclo[5.4.0] undec-7-ene; diphenyl phosphoryl azide / 1,4-dioxane / 70 °C

6.1: hydrogen; pyrographite; palladium / 1,4-dioxane / 16 h / 20 °C / 760.05 Torr

With sodium periodate; osmium(VIII) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0] undec-7-ene; hydrogen; pyrographite; palladium; 4-methylmorpholine N-oxide; lithium tri-t-butoxyaluminum hydride; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; water; acetone;

DOI:10.1021/ml200252b

Reference yield:

2-(trifluoromethyl)biphenyl-4-amine → 8-(aminomethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide (1351945-12-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 17 h / 60 °C

2.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; cesium fluoride / 1,4-dioxane / 16 h / 50 °C / Inert atmosphere

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 20 °C

4.1: sodium periodate / water; acetone / 20 °C

5.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 0.5 h / Inert atmosphere

5.2: 0.5 h

6.1: 1,8-diazabicyclo[5.4.0] undec-7-ene; diphenyl phosphoryl azide / 1,4-dioxane / 70 °C

7.1: hydrogen; pyrographite; palladium / 1,4-dioxane / 16 h / 20 °C / 760.05 Torr

With sodium periodate; osmium(VIII) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0] undec-7-ene; hydrogen; pyrographite; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium; 4-methylmorpholine N-oxide; lithium tri-t-butoxyaluminum hydride; triethylamine; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ml200252b

upstream raw materials:

8-chloro-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

8-ethenyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

8-(1,2-dihydroxyethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

8-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1,4-dihydroquinoline-3-carboxamide

Refernces