4-ISOBUTOXY-BENZOIC ACID

Base Information

• Chemical Name: 4-ISOBUTOXY-BENZOIC ACID
• CAS No.: 30762-00-6
• Molecular Formula: C11H14 O3
• Molecular Weight: 194.23
• Hs Code.: 2918990090
• Mol file: 30762-00-6.mol

Synonyms:Benzoicacid, p-isobutoxy- (6CI,8CI); 4-Isobutoxybenzoic acid; p-Isobutoxybenzoic acid

Chemical Property of 4-ISOBUTOXY-BENZOIC ACID

Chemical Property:

• Vapor Pressure: 0.000232mmHg at 25°C
• Boiling Point: 312°Cat760mmHg
• Flash Point: 118.5°C
• PSA: 46.53000
• Density: 1.104g/cm³
• LogP: 2.41960

Purity/Quality:

98%Min ^*data from raw suppliers

4-IsobutoxybenzoicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ISOBUTOXY-BENZOIC ACID

There total 12 articles about 4-ISOBUTOXY-BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 4-(2-methylpropoxy)benzoate (124403-90-3) → 4-isobutoxybenzoic acid (30762-00-6)

Guidance literature:

With water; sodium hydroxide; In methanol; for 18h; Time;

Reference yield: 44.2%

carbon dioxide (124-38-9,18923-20-1) + 4-bromophenyl iso-butyl ether (30752-23-9) → 4-isobutoxybenzoic acid (30762-00-6)

Guidance literature:

4-bromophenyl iso-butyl ether; With n-butyllithium; In tetrahydrofuran; diethyl ether; at -70 ℃; for 1h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; diethyl ether;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; water; pH=6;

DOI:10.1016/j.tca.2015.07.011

Reference yield:

2-methyl-propan-1-ol (78-83-1) + dibenzoyl peroxide (94-36-0) → isobutyl salicylate (87-19-4) + 4-isobutoxybenzoic acid (30762-00-6) + methylammonium carbonate (15719-64-9,15719-76-3,97762-63-5) + biphenyl-4-carboxylic acid (92-92-2)

Guidance literature:

upstream raw materials:

ethyl 4-(2-methylpropoxy)benzoate

Isobutyl bromide

methyl 4-hydroxylbenzoate

Isobutyl iodide

Downstream raw materials:

1-[4-(2-methylpropyloxy)phenyl]methanamine

4-isobutoxybenzamide

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

4-(2-methylpropoxy)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)-quinolin-7-yl]benzamide

Refernces

• 1、 -. "COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES". Paragraph 00271; 00272; 00275; 00276; 00328; 00329; 00330. . Retrieved 2019/03/12.
• 2、 -. "COMPOUNDS FOR MODULATING AQUAPORINS". Page/Page column 48; 49-50. . Retrieved 2017/12/08.