2,3,5,6-Tetrakis(2-pyridyl)pyrazine

Base Information

• Chemical Name: 2,3,5,6-Tetrakis(2-pyridyl)pyrazine
• CAS No.: 25005-97-4
• Deprecated CAS: 1810709-53-5,1817698-26-2
• Molecular Formula: C24H16N6
• Molecular Weight: 388.431
• Hs Code.: 2933990090
• European Community (EC) Number: 627-885-1
• DSSTox Substance ID: DTXSID70885280
• Nikkaji Number: J422.149D
• Wikidata: Q82863896
• Mol file: 25005-97-4.mol

Synonyms:2,3,5,6-tetrakis(2-pyridyl)pyrazine

Chemical Property of 2,3,5,6-Tetrakis(2-pyridyl)pyrazine

Chemical Property:

• Vapor Pressure: 2.18E-10mmHg at 25°C
• Melting Point: 292-294 °C(lit.)
• Refractive Index: 1.65
• Boiling Point: 519.8 °C at 760 mmHg
• PKA: -2.68±0.19(Predicted)
• Flash Point: 265.3 °C
• PSA: 77.34000
• Density: 1.253 g/cm³
• LogP: 4.72460
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 388.14364454
• Heavy Atom Count: 30
• Complexity: 440

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tetra-2-pyridinylpyrazine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C2=C(N=C(C(=N2)C3=CC=CC=N3)C4=CC=CC=N4)C5=CC=CC=N5
• Uses: Tetra-2-pyridinylpyrazine (tppz, tpyprz) may be used as a ligand in the synthesis of the following metal complexes:[{CuCl}2(μ-tppz)][PF6]2 (PF6=hexafluorophosphate)[(Cp*2Ln)2(μ-tppz.)](BPh4) (Cp*=pentamethylcyclopentadienyl; Ln=Gd, Tb, Dy; BPh4=tetraphenyl borate)[Fe(tpyprz)2]2[Mo8O26]·3.7H2O (Mo8O26=octamolybdate)

Technology Process of 2,3,5,6-Tetrakis(2-pyridyl)pyrazine

There total 4 articles about 2,3,5,6-Tetrakis(2-pyridyl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

{Fe(tetrakis(2-pyridyl)-1,4-diazine)}I2 → Na{Fe(CN)3(tetrakis(2-pyridyl)-1,4-diazine)}*3H2O + 2,3,5,6-tetrakis(2-pyridyl)pyrazine (25005-97-4)

Guidance literature:

With sodium cyanide; In water; under Ar, addn. of solid NaCN to a hot soln. of Fe-compd. in H2O, kept hot for 5 h; cooled to room temp., filtered, eluted down a Sephadex C-25 cation-exchange resin with water, evapd. to dryness, dissolved in methanol, filtered, pptd. by addn. of diethyl ether, collected, washed with acetone, air-dried; elem. anal.;

Reference yield: 48.0%

2-(Aminomethyl)pyridine (3731-51-9) → 2,3,5,6-tetrakis(2-pyridyl)pyrazine (25005-97-4)

Guidance literature:

With cobalt(II) chloride; In ethanol; for 3.5h; Heating; aeration;

DOI:10.3987/com-02-s33

Reference yield: 37.0%

2-(Aminomethyl)pyridine (3731-51-9) → 2,3,5,6-tetrakis(2-pyridyl)pyrazine (25005-97-4) + 2,4,5-(tripyridin-2-yl)oxazole (93366-61-1)

Guidance literature:

With cobalt(II) chloride; In water;

upstream raw materials:

2-hydroxy-1,2-di-2-pyridylethanone

ammonium acetate

2-(Aminomethyl)pyridine

Downstream raw materials:

[Zn(tpyprz)(1,2-HO₃PC₈H₈PO₃H)]

Refernces

• 1、 Ogura, Kuniyoshi,Kurasawa, Yoshihisa,Yamaguchi, Yoshimi,Okamoto, Yoshihisa. "The aerial oxidation of a cobalt(II)-2-aminomethylpyridine complex: An improved method for synthesis of 2,3,5,6-(tetrapyridin-2-yl) pyrazine". . p. 283 - 291. Retrieved 2007/10/03.
• 2、 Okamoto, Yoshihisa,Ogura, Kuniyoshi,Kinoshita, Toshio. "A METAL MEDIATED SYNTHESIS OF CHELATE REAGENT: 2,3,5,6-TETRA (α-PYRIDYL)PYRAZINE". . p. 662. Retrieved 2007/10/02.