Technology Process of (E)-methyl 3-(3-(N-(2-(6-methoxypyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate
There total 11 articles about (E)-methyl 3-(3-(N-(2-(6-methoxypyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)sulfamoyl)phenyl)acrylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
tetrakis(triphenylphosphine) palladium(0);
In
water; dimethyl sulfoxide;
at 120 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium methylate / N,N-dimethyl-formamide
2.1: hydrogenchloride; iron / ethanol; water / 2 h / Reflux
3.1: hydrogenchloride; sodium nitrite; acetic acid / water / -10 - 5 °C
3.2: 0.5 h / 0 °C
4.1: sodium hydride / tetrahydrofuran / 3 h / 20 °C
4.2: 3 h / Reflux
5.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / water; dimethyl sulfoxide / 4 h / 120 °C
With
hydrogenchloride; sodium methylate; iron; sodium hydride; sodium hydrogencarbonate; acetic acid; sodium nitrite;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; iron / ethanol; water / 2 h / Reflux
2.1: hydrogenchloride; sodium nitrite; acetic acid / water / -10 - 5 °C
2.2: 0.5 h / 0 °C
3.1: sodium hydride / tetrahydrofuran / 3 h / 20 °C
3.2: 3 h / Reflux
4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / water; dimethyl sulfoxide / 4 h / 120 °C
With
hydrogenchloride; iron; sodium hydride; sodium hydrogencarbonate; acetic acid; sodium nitrite;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; water; dimethyl sulfoxide;