(2S,3aS,7aS)-1-glycinyl>-2-carboxyperhydroindole

Base Information

• Chemical Name: (2S,3aS,7aS)-1-glycinyl>-2-carboxyperhydroindole
• CAS No.: 130933-17-4
• Molecular Formula: C₁₆H₂₆N₂O₅
• Molecular Weight: 326.393
• Mol file: 130933-17-4.mol

Synonyms:(2S,3aS,7aS)-1-glycinyl>-2-carboxyperhydroindole

Chemical Property of (2S,3aS,7aS)-1-glycinyl>-2-carboxyperhydroindole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (2S,3aS,7aS)-1-glycinyl>-2-carboxyperhydroindole

There total 1 articles about (2S,3aS,7aS)-1-glycinyl>-2-carboxyperhydroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid phenylmethyl ester 4-methylbenzenesulfonate (94062-52-9,82717-91-7) → (2S,3aS,7aS)-1-glycinyl>-2-carboxyperhydroindole (130933-17-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / Et₃N, HOBT, DCC / dimethylformamide / 20 h / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol / 18 h / 2206.5 Torr / Ambient temperature

3: 72 percent / 0.2 N aq. NaOH / 72 h

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00106a030

upstream raw materials:

(2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid phenylmethyl ester 4-methylbenzenesulfonate

Refernces