Technology Process of N-{[3-(trifluoromethyl)phenyl]thio}phthalimide
There total 3 articles about N-{[3-(trifluoromethyl)phenyl]thio}phthalimide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
m-trifluoromethylphenyl iodide;
With
TurboGrignard;
In
tetrahydrofuran;
Inert atmosphere;
Schlenk technique;
With
zinc(II) chloride;
In
tetrahydrofuran;
at -20 ℃;
for 1h;
Inert atmosphere;
Schlenk technique;
phthalimidesulfenyl chloride;
In
tetrahydrofuran; dichloromethane;
at 0 - 25 ℃;
for 0.833333h;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/anie.202009699
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: disulfur dichloride; triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2.1: sulfuryl dichloride; pyridine / dichloromethane / 48 h / 20 °C / Inert atmosphere; Schlenk technique
3.1: TurboGrignard / tetrahydrofuran / Inert atmosphere; Schlenk technique
3.2: 1 h / -20 °C / Inert atmosphere; Schlenk technique
3.3: 0.83 h / 0 - 25 °C / Inert atmosphere; Schlenk technique
With
pyridine; disulfur dichloride; TurboGrignard; sulfuryl dichloride; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.202009699
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sulfuryl dichloride; pyridine / dichloromethane / 48 h / 20 °C / Inert atmosphere; Schlenk technique
2.1: TurboGrignard / tetrahydrofuran / Inert atmosphere; Schlenk technique
2.2: 1 h / -20 °C / Inert atmosphere; Schlenk technique
2.3: 0.83 h / 0 - 25 °C / Inert atmosphere; Schlenk technique
With
pyridine; TurboGrignard; sulfuryl dichloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.202009699