Senegenin

Base Information

• Chemical Name: Senegenin
• CAS No.: 2469-34-3
• Molecular Formula: C30H45ClO6
• Molecular Weight: 537.137
• European Community (EC) Number: 683-152-6
• UNII: 06S1QH951L
• DSSTox Substance ID: DTXSID90947632
• Nikkaji Number: J7.584A
• Wikidata: Q27236217
• Mol file: 2469-34-3.mol

Synonyms:12-(Chloromethyl)-2b,3b-dihydroxy-27;senegenin;tenuigenin

Chemical Property of Senegenin

Chemical Property:

• Vapor Pressure: 4.64E-21mmHg at 25°C
• Melting Point: 290-292 °C
• Refractive Index: 1.591
• Boiling Point: 674.1 °C at 760 mmHg
• PKA: 4.27±0.70(Predicted)
• Flash Point: 361.5 °C
• PSA: 115.06000
• Density: 1.29 g/cm³
• LogP: 5.48800
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble10mg/mL, clear
• XLogP3: 5.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 536.2904668
• Heavy Atom Count: 37
• Complexity: 1040

Purity/Quality:

99.5% ^*data from raw suppliers

Senegenin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCC2(CCC3=C(C2C1)C(CC4C3(CCC5C4(CC(C(C5(C)C(=O)O)O)O)C)C)CCl)C(=O)O)C
• Isomeric SMILES: C[C@@]12CC[C@@H]3[C@@]([C@H]1C[C@@H](C4=C2CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)CCl)(C[C@@H]([C@@H]([C@@]3(C)C(=O)O)O)O)C
• Description: Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.
• Uses: Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.

Technology Process of Senegenin

There total 2 articles about Senegenin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Senegenin (2469-34-3,667438-01-9)

Guidance literature:

Senegenin-monoacetat, wss.-methanol. HCl, Δ;

DOI:10.1139/v64-073

Reference yield:

→ Senegenin (2469-34-3,667438-01-9)

Guidance literature:

Pre-senegenin, wss. HCl, wss. A., Δ; (neben Polygalsaeure);

DOI:10.1139/v65-273