Sodium L-pyroglutamate

Base Information

• Chemical Name: Sodium L-pyroglutamate
• CAS No.: 28874-51-3
• Molecular Formula: C5H6NNaO3
• Molecular Weight: 151.097
• Hs Code.: 2933790090
• Mol file: 28874-51-3.mol

Synonyms:L-Proline,5-oxo-, monosodium salt (9CI);Proline, 5-oxo-, monosodium salt, L- (8CI);2-Pyrrolidinone-5-carboxylic acid sodium salt;2-Pyrrolidone-5-carboxylic acidsodium salt;5-Carboxy-2-pyrrolidone sodium salt;Ajidew N 50;Ajidew NL 50;PDSI 101;Sodium 2-oxo-5-pyrrolidinecarboxylate;Sodium2-pyrrolidinone-5-carboxylate;Sodium 2-pyrrolidone-5-carboxylate;Sodium L-pyrrolidonecarboxylate;Sodium pidolate;Sodium pyroglutamate;

Chemical Property of Sodium L-pyroglutamate

Chemical Property:

• Appearance/Colour: Pale yellow transparent liquid
• Vapor Pressure: 1.79E-09mmHg at 25°C
• Melting Point: 125 °C
• Boiling Point: 453.1 °C at 760 mmHg
• PKA: 9.94[at 20 ℃]
• Flash Point: 227.8 °C
• PSA: 69.23000
• Density: 1.45
• LogP: -1.65630
• Storage Temp.: Refrigerator
• Solubility.: Methanol (Sparingly), Water
• Water Solubility.: 613g/L at 20℃

Purity/Quality:

50% ^*data from raw suppliers

SodiumL-Pyroglutamate(TechnicalGrade) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: sodium PCA (Ajidew NaPCA, Nalidone) is a high-performance humectant given its moisture-binding ability. Sodium PCA is a component of the skin’s natural moisturizing factor. For cosmetic use, it is derived from amino acids. It is considered a noncomedogenic, non-allergenic raw material recommended for dry, delicate, and sensitive skins.

Technology Process of Sodium L-pyroglutamate

There total 3 articles about Sodium L-pyroglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-L-pyrrolidone-5-carboxylic acid (98-79-3) → sodium hydrogen bis-L-pyroglutamate (28874-51-3,37675-88-0,54571-67-4,60373-59-3,68766-98-3)

Guidance literature:

With sodium hydroxide; In water; for 3h; Ambient temperature;

Reference yield:

monosodium glutamate (142-47-2) → sodium L-pyroglutamate (28874-51-3)

Guidance literature:

In water; at 180 ℃; for 2h;

Reference yield:

glutamic acid sodium salt (142-47-2,149-65-5,15383-53-6,16079-50-8,16177-21-2,16690-92-9,21932-17-2,26247-79-0,28223-73-6,30617-64-2,30811-79-1,32221-81-1,32342-59-9,56-86-0) → sodium L-pyroglutamate (28874-51-3)

Guidance literature:

In water; at 180 ℃; for 2h;

upstream raw materials:

monosodium glutamate

glutamic acid sodium salt

2-L-pyrrolidone-5-carboxylic acid

Downstream raw materials:

Succinimide

Refernces

• 1、 -. "Zinc pyrrolidonecarboxylate dihydrate and method of producing the same". Page/Page column 7, 8. . Retrieved 2008/06/13.