Technology Process of N-Hydroxy-4-(3-methyl-2-oxo-1-phenyl-pyrrolidin-3-ylamino)-benzamide
There total 7 articles about N-Hydroxy-4-(3-methyl-2-oxo-1-phenyl-pyrrolidin-3-ylamino)-benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydroxylamine monohydrate;
In
methanol;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ammonia / water; acetonitrile / 40 °C
2.1: caesium carbonate / (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-dimethyl-amine; copper(I) bromide / N,N-dimethyl-formamide / 100 °C / Inert atmosphere
3.1: dmap / acetonitrile / 12 h / 20 °C
4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
4.2: 20 °C
5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C
6.1: hydroxylamine monohydrate / methanol / 2 h / 20 °C
With
hydroxylamine monohydrate; ammonia; caesium carbonate; trifluoroacetic acid; lithium diisopropyl amide;
dmap; (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-dimethyl-amine; copper(I) bromide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium phosphate / acetonitrile / 1 h / 0 - 20 °C
2.1: ammonia / water; acetonitrile / 40 °C
3.1: caesium carbonate / (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-dimethyl-amine; copper(I) bromide / N,N-dimethyl-formamide / 100 °C / Inert atmosphere
4.1: dmap / acetonitrile / 12 h / 20 °C
5.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
5.2: 20 °C
6.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C
7.1: hydroxylamine monohydrate / methanol / 2 h / 20 °C
With
potassium phosphate; hydroxylamine monohydrate; ammonia; caesium carbonate; trifluoroacetic acid; lithium diisopropyl amide;
dmap; (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-dimethyl-amine; copper(I) bromide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;