(R)-fenoprofen di(1-naphthyl)methyl ester

Base Information

• Chemical Name: (R)-fenoprofen di(1-naphthyl)methyl ester
• CAS No.: 1116086-48-6
• Molecular Formula: C₃₆H₂₈O₃
• Molecular Weight: 508.617
• Mol file: 1116086-48-6.mol

Synonyms:(R)-fenoprofen di(1-naphthyl)methyl ester

Chemical Property of (R)-fenoprofen di(1-naphthyl)methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-fenoprofen di(1-naphthyl)methyl ester

There total 2 articles about (R)-fenoprofen di(1-naphthyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fenoprofen (29679-58-1,31879-05-7,32953-79-0) + bis(1-naphthyl)methanol (62784-66-1) → (R)-fenoprofen di(1-naphthyl)methyl ester (1116086-48-6) + (S)-fenoprofen di(1-naphthyl)methyl ester + (S)-fenoprofen (33028-97-6,31879-05-7,32953-79-0) + (R)-fenoprofen (31879-05-7,32953-79-0)

Guidance literature:

With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; p-Methoxybenzoic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h; optical yield given as %ee; Resolution of racemate;

DOI:10.1002/ejoc.200800942

Reference yield:

→ (R)-fenoprofen di(1-naphthyl)methyl ester (1116086-48-6) + (S)-fenoprofen di(1-naphthyl)methyl ester

Guidance literature:

With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; 2,2-dimethylpropanoic anhydride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Overall yield = 95 %;

upstream raw materials:

Fenoprofen

bis(1-naphthyl)methanol

Refernces

• 1、 -. "Method for manufacturing optically active carboxylic acid ester". Page/Page column 21; 22. . Retrieved 2016/05/11.
• 2、 -. "METHOD FOR PRODUCING OPTICALLY ACTIVE ESTER AND METHOD FOR PRODUCING OPTICALLY ACTIVE CARBOXYLIC ACID". Page/Page column 15-16. . Retrieved 2010/09/18.