Meteneprost

Base Information

• Chemical Name: Meteneprost
• CAS No.: 61263-35-2
• Molecular Formula: C₂₃H₃₈O₄
• Molecular Weight: 378.552
• UNII: 269EB4R1TV
• DSSTox Substance ID: DTXSID001018145
• Nikkaji Number: J18.321K
• Wikidata: Q27254077
• NCI Thesaurus Code: C90926
• Metabolomics Workbench ID: 2420
• ChEMBL ID: CHEMBL3989772
• Mol file: 61263-35-2.mol

Synonyms:9-deoxo-16,16-dimethyl-9-methylene-PGE2;9-deoxo-16,16-dimethyl-9-methyleneprostaglandin E2;9-deoxy-16,16-dimethyl-9-methylene-PGF2;9-methylene-16,16-dimethyl PGE2;9-methylene-PGE2;meteneprost

Chemical Property of Meteneprost

Chemical Property:

• Vapor Pressure: 5.22E-13mmHg at 25°C
• Refractive Index: 1.4433 (estimate)
• Boiling Point: 520.5 °C at 760 mmHg
• PKA: 4.76±0.10(Predicted)
• Flash Point: 282.6 °C
• PSA: 77.76000
• Density: 1.04 g/cm³
• LogP: 4.87430
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 12
• Exact Mass: 378.27700969
• Heavy Atom Count: 27
• Complexity: 533

Purity/Quality:

95-99% ^*data from raw suppliers

Meteneprost ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC(C)(C)C(C=CC1C(CC(=C)C1CC=CCCCC(=O)O)O)O
• Isomeric SMILES: CCCCC(C)(C)[C@@H](/C=C/[C@H]1[C@@H](CC(=C)[C@@H]1C/C=C\CCCC(=O)O)O)O
• Uses: Meteneprost is a potent analog of Prostaglandin E2 (PGE2) (P838610). Meteneprost in combination with various other prostaglandin derivatives is used for medical termination of early pregnancy. 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 (PGE2; ) with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the termination of first trimester pregnancy in monkeys. A single intramuscular injection containing 0.5 mg of meteneprost and 7.5 mg of 17-phenyl trinor PGF1α is very effective in terminating early pregnancy. This prostaglandin mixture is ineffective on monkeys in their third trimester of pregnancy. Meteneprost, when compared to PGE2 and PGF1α, in monkey and rat, does not result in unwanted side effects such as fever or gastrointestinal problems.

Technology Process of Meteneprost

There total 1 articles about Meteneprost which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ meteneprost (61263-35-2)

Guidance literature:

Entspr. Methylester, Hydrolyse;

Refernces

• 1、 -. "Intermediates for the production of prostaglandins from D-glucose". . . Retrieved 2008/06/13.