Alipamide

Base Information

• Chemical Name: Alipamide
• CAS No.: 3184-59-6
• Molecular Formula: C₉H₁₂ClN₃O₃S
• Molecular Weight: 277.732
• Hs Code.: 2935009090
• UNII: PE8925K9EY
• DSSTox Substance ID: DTXSID40185704
• Nikkaji Number: J7.687B
• Wikidata: Q27286504
• NCI Thesaurus Code: C81071
• ChEMBL ID: CHEMBL2106662
• Mol file: 3184-59-6.mol

Synonyms:ALIPAMIDE;3184-59-6;Alipamidum;Alipamid;Alipamida;CI-546;UNII-PE8925K9EY;Alipamide [USAN:INN:BAN];CN-38,474;PE8925K9EY;Benzoic acid, 4-chloro-3-sulfamoyl-, 2,2-dimethylhydrazide;D-1721;CI 546;4-Chloro-3-sulfamoylbenzoic acid 2,2-dimethylhydrazide;CN 38474;CN-38474;D 1721;4-Chlor-2,2'-dimethyl-3-sulfamoylbenzohydrazid;Benzoic acid, 3-(aminosulfonyl)-4-chloro-2,2-dimethylhydrazide;2-chloro-5-(dimethylaminocarbamoyl)benzenesulfonamide;ALIPAMIDE [INN];Alipamide (USAN/INN);ALIPAMIDE [USAN];C9H12ClN3O3S;SCHEMBL120853;CHEMBL2106662;DTXSID40185704;AKOS040750321;D02813;Q27286504;2-chloro-5-[(2,2-dimethylhydrazino)carbonyl]benzenesulfonamide;Benzoic acid, 3-(aminosulfonyl)-4-chloro-, 2,2-dimethylhydrazide

Chemical Property of Alipamide

Chemical Property:

• Melting Point: 185-188 °C(Solv: water (7732-18-5))
• Boiling Point: °Cat760mmHg
• PKA: 9.38±0.60(Predicted)
• Flash Point: °C
• PSA: 104.37000
• Density: 1.428g/cm³
• LogP: 2.54970
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 277.0287901
• Heavy Atom Count: 17
• Complexity: 379

Purity/Quality:

≥98% ^*data from raw suppliers

2-CHLORO-5-[(2,2-DIMETHYLHYDRAZINO)CARBONYL]BENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)NC(=O)C1=CC(=C(C=C1)Cl)S(=O)(=O)N
• Uses: Diuretic; antihypertensive.

Technology Process of Alipamide

There total 3 articles about Alipamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-3-sulphamoylbenzoic acid (1205-30-7) → Alipamide (3184-59-6)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / Heating

2: diethyl ether

With thionyl chloride; In diethyl ether;

DOI:10.1021/jm00311a012

Reference yield:

3-(aminosulfonyl)-4-chlorobenzoyl chloride (70049-77-3) + N,N-Dimethylhydrazine (57-14-7) → Alipamide (3184-59-6)

Guidance literature:

In diethyl ether;

DOI:10.1021/jm00311a012

Reference yield:

→ Alipamide (3184-59-6)

Guidance literature:

Cyanomethyl-4-chlor-3-sulfamoylbenzoat, H2N-NMe2;

upstream raw materials:

3-(aminosulfonyl)-4-chlorobenzoyl chloride

N,N-Dimethylhydrazine

4-chloro-3-sulphamoylbenzoic acid

Refernces