N-(p-chlorophenyl)phenylacetamidine

Base Information

• Chemical Name: N-(p-chlorophenyl)phenylacetamidine
• CAS No.: 7118-58-3
• Molecular Formula: C₁₄H₁₃ClN₂
• Molecular Weight: 244.724
• Mol file: 7118-58-3.mol

Synonyms:N-(p-chlorophenyl)phenylacetamidine

Chemical Property of N-(p-chlorophenyl)phenylacetamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(p-chlorophenyl)phenylacetamidine

There total 4 articles about N-(p-chlorophenyl)phenylacetamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

phenylacetonitrile (140-29-4) + 4-chloro-aniline (106-47-8) → N'-(4-chlorophenyl)-2-phenylacetimidamide (7118-58-3)

Guidance literature:

4-chloro-aniline; With trimethylaluminum; In toluene; at 0 - 20 ℃; for 0.5h;

phenylacetonitrile; In toluene; at 60 ℃; for 10h;

DOI:10.5012/bkcs.2013.34.4.1266

Reference yield: 59.0%

phenylacetonitrile (140-29-4) + 4-chlorobenzonitrile (100-00-5) → N-(p-chlorophenyl)phenylacetamidine (7118-58-3)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1039/a803077d

Reference yield:

→ N'-(4-chlorophenyl)-2-phenylacetimidamide (7118-58-3)

Guidance literature:

Benzylcyanid, N-Li-p-chloranilid, Ether, Δ;

upstream raw materials:

phenylacetonitrile

4-chloro-aniline

4-chlorobenzonitrile

Downstream raw materials:

[3-Benzyl-2-(4-chloro-phenyl)-2H-[1,2,4]thiadiazol-(5E)-ylidene]-phenyl-amine

6-Amino-2-(4-chloro-phenylamino)-4,5-diphenyl-nicotinonitrile

2-benzyl-5-chloro-1H-benzo[d]imidazole

2-Amino-1-(4-chloro-phenyl)-6-imino-4,5-diphenyl-1,6-dihydro-pyridine-3-carbonitrile

Refernces

• 1、 Zhou, Longhu,Zhang, Yongmin. "Samarium(II) iodide induced reductive coupling of nitriles with nitro compounds". . p. 2899 - 2902. Retrieved 2007/10/03.
• 2、 Zhou, Longhu,Zhang, Yongmin. "Low-valent titanium induced reductive coupling of nitriles with nitro compounds". . p. 3249 - 3262. Retrieved 2007/10/03.