5-(4'-methylbenzoyl)-3-trifluoroacetylindole

Base Information

• Chemical Name: 5-(4'-methylbenzoyl)-3-trifluoroacetylindole
• CAS No.: 626234-76-2
• Molecular Formula: C₁₈H₁₂F₃NO₂
• Molecular Weight: 331.294
• Mol file: 626234-76-2.mol

Synonyms:5-(4'-methylbenzoyl)-3-trifluoroacetylindole

Chemical Property of 5-(4'-methylbenzoyl)-3-trifluoroacetylindole

Chemical Property:

Purity/Quality:

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Technology Process of 5-(4'-methylbenzoyl)-3-trifluoroacetylindole

There total 1 articles about 5-(4'-methylbenzoyl)-3-trifluoroacetylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2,2,2-trifluoro-1-(1H-indol-3-yl)ethanone (14618-45-2) + 4-methyl-benzoyl chloride (874-60-2) → 5-(4'-methylbenzoyl)-3-trifluoroacetylindole (626234-76-2)

Guidance literature:

With aluminium trichloride; In nitromethane; at 20 ℃; for 16h;

DOI:10.1055/s-2003-40864

Reference yield: 99.0%

5-(4'-methylbenzoyl)-3-trifluoroacetylindole (626234-76-2) → 5-(4'-methylbenzoyl)indole-3-carboxylic acid (626234-86-4)

Guidance literature:

With potassium hydroxide; Heating;

DOI:10.1055/s-2003-40864

Reference yield:

5-(4'-methylbenzoyl)-3-trifluoroacetylindole (626234-76-2) → (1H-indol-5-yl)(4'-tolyl)methanone

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / aq. KOH / Heating

2: 79 percent / quinoline; 5-(4'-methylbenzoyl)indole-3-carboxylic acid cupric(II) salt / 0.75 h / 150 °C

With quinoline; potassium hydroxide; 5-(4'-methylbenzoyl)indole-3-carboxylic acid cupric(II) salt;

DOI:10.1055/s-2003-40864

upstream raw materials:

2,2,2-trifluoro-1-(1H-indol-3-yl)ethanone

4-methyl-benzoyl chloride

Downstream raw materials:

5-(4'-methylbenzoyl)indole-3-carboxylic acid

Refernces