Benzoic acid, 2-aMino-3-Methoxy-, hydrochloride

Base Information

• Chemical Name: Benzoic acid, 2-aMino-3-Methoxy-, hydrochloride
• CAS No.: 68701-23-5
• Molecular Formula: C₈H₉NO₃*ClH
• Molecular Weight: 203.625
• Mol file: 68701-23-5.mol

Synonyms:2-amino-3-methoxybenzoic acid hydrochloride

Chemical Property of Benzoic acid, 2-aMino-3-Methoxy-, hydrochloride

Chemical Property:

Purity/Quality:

98%+ ^*data from raw suppliers

2-Amino-3-methoxybenzoicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 2-aMino-3-Methoxy-, hydrochloride

There total 6 articles about Benzoic acid, 2-aMino-3-Methoxy-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-2-[(2-oxobutanoyl)amino]benzoic acid (1513883-15-2) → 2-amino-3-methoxybenzoic acid hydrochloride (68701-23-5)

Guidance literature:

With hydrogenchloride; water; for 1h; Reflux;

DOI:10.1016/j.tet.2013.10.092

Reference yield:

N-(2-methoxy-6-methylphenyl)acetamide (50868-76-3) → 2-amino-3-methoxybenzoic acid hydrochloride (68701-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 4.5 g / KMnO₄ / H₂O / Heating

2: conc. HCl / Heating

With hydrogenchloride; potassium permanganate; In water;

DOI:10.1007/BF00579645

Reference yield:

1-methoxy-3-methyl-2-nitro-benzene (5345-42-6) → 2-amino-3-methoxybenzoic acid hydrochloride (68701-23-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) SnCl*2H₂O, conc. HCl; 2) pyridine

2: 4.5 g / KMnO₄ / H₂O / Heating

3: conc. HCl / Heating

With pyridine; hydrogenchloride; potassium permanganate; SnCl*2H₂O; In water;

DOI:10.1007/BF00579645

upstream raw materials:

7-methoxy-1H-indole-2,3-dione

2-acetamido-3-methoxybenzoic acid

N-(2-methoxy-6-methylphenyl)acetamide

1-methoxy-3-methyl-2-nitro-benzene

Downstream raw materials:

8-methoxydeoxyvasicinone

8-hydroxy-3,4-dihydro-2,3-pentamethylenequinazolone

Refernces

• 1、 Karimov, A.,Telezhenetskaya, M. V.,Yunusov, S. Yu.. "SYNTHETIC ANALOGS OF Peganum ALKALOIDS. I. SYNTHESIS OF METHOXY- AND HYDROXY-SUBSTITUTED DEOXYVASICINONES AND DEOXYPEGANINES". . p. 466 - 472. Retrieved 2007/10/02.