(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenylmethacrylate mandelate

Base Information Edit

Chemical Name:(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenylmethacrylate mandelate
CAS No.:1390644-38-8
Molecular Formula:C₈H₈O₃*C₂₆H₃₅NO₃
Molecular Weight:561.719
Hs Code.:
Mol file:1390644-38-8.mol

Synonyms:(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenylmethacrylate mandelate

Suppliers and Price of (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenylmethacrylate mandelate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenylmethacrylate mandelate Edit

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenylmethacrylate mandelate

There total 23 articles about (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenylmethacrylate mandelate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 156755-20-3
PNU 200577 l-mandelate salt

: 920-46-7,26937-45-1
Methacryloyl chloride

: 1390644-38-8
(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenylmethacrylate mandelate

Guidance literature:: PNU 200577 l-mandelate salt; With sodium carbonate; In chloroform; water; at 0 - 5 ℃; for 0.25h;

Methacryloyl chloride; With potassium carbonate; In chloroform; at -45 - -35 ℃; for 0.75h;

With (S)-Mandelic acid; In ethyl acetate; at 0 - 50 ℃;

Reference yield:

: 621-82-9
Cinnamic acid

: 1390644-38-8
(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenylmethacrylate mandelate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; acetic acid / 16 h / 100 °C

2.1: acetone / 2 h / 25 - 35 °C

3.1: boron trifluoride diethyl etherate / tetrahydrofuran / 1 h / -20 °C

4.1: hydrogen / 5%-palladium/activated carbon / methanol / 18 h / 25 - 35 °C / 2942.29 Torr / autoclave

5.1: potassium carbonate / acetone / 6 h / Reflux

6.1: isopropyl alcohol / 0.5 h / Reflux

7.1: sodium carbonate / chloroform; water / 0.25 h / 0 - 5 °C

7.2: 0.75 h / -45 - -35 °C

7.3: 0 - 50 °C

With sulfuric acid; boron trifluoride diethyl etherate; hydrogen; sodium carbonate; potassium carbonate; acetic acid; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; chloroform; water; isopropyl alcohol; acetone;

Reference yield:

: (+/-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropane-1-ol

: 1390644-38-8
(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenylmethacrylate mandelate

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C

2.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere

3.1: isopropyl alcohol / 30 - 55 °C

4.1: sodium hydroxide; water / dichloromethane / 0.25 h / 10 - 20 °C / pH 11.5

4.2: 4 h / 25 - 55 °C / Inert atmosphere

4.3: -70 - -10 °C / Inert atmosphere

5.1: thionyl chloride / 5 h / 40 - 45 °C

6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 4 h / 0 - 5 °C / Inert atmosphere

7.1: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 25 - 30 °C / 2206.72 - 2942.29 Torr

8.1: isopropyl alcohol / 0.5 h / Reflux

9.1: sodium carbonate / chloroform; water / 0.25 h / 0 - 5 °C

9.2: 0.75 h / -45 - -35 °C

9.3: 0 - 50 °C

With dmap; thionyl chloride; water; hydrogen; sodium carbonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium hydroxide; 5%-palladium/activated carbon; In methanol; dichloromethane; chloroform; water; isopropyl alcohol; toluene; acetonitrile;