Orotic acid sodium salt

Base Information

• Chemical Name: Orotic acid sodium salt
• CAS No.: 154-85-8
• Molecular Formula: C5H4 N2 O4 . Na
• Molecular Weight: 178.08
• Hs Code.: 2933599090
• Mol file: 154-85-8.mol

Synonyms:Orotic acid sodium salt;SCHEMBL193603;sodium 2,6-dihydroxy-4-pyrimidinecarboxylate

Chemical Property of Orotic acid sodium salt

Chemical Property:

• PSA: 105.85000
• LogP: -2.57330
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 179.00687590
• Heavy Atom Count: 12
• Complexity: 268

Purity/Quality:

99% ^*data from raw suppliers

OroticAcidMonosodiumSalt ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(NC(=O)NC1=O)C(=O)O.[Na]
• Uses: Orotic Acid Monosodium Salt is used in the formation of a complex with lanthanium(III) which displats cytotoxic activity on different tumor cell lines.Also, it is the unlabeled form of Orotic Acid-15N2 Monosodium Salt (O691517), which is an intermediate used in the synthesis of Orotic Acid-15N2 Monohydrate (O691504), which is a labeled analogue of Orotic Acid Monohydrade (O691500), which is used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment.

Technology Process of Orotic acid sodium salt

There total 4 articles about Orotic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

orotic acid (65-86-1,58915-47-2,6784-70-9) → orotic acid sodium salt (154-85-8)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; Reflux;

DOI:10.1016/j.ejmech.2012.11.023

Reference yield:

6-Methyluracil (626-48-2) → orotic acid sodium salt (154-85-8)

Guidance literature:

With water; oxygen; sodium hydroxide; at 95 ℃;

Reference yield:

orotic acid (65-86-1,58915-47-2,6784-70-9) + 6-trichloromethyl-1H-pyrimidine-2,4-dione (62881-01-0) → orotic acid sodium salt (154-85-8)

Guidance literature:

With sodium hydroxide; In water;

upstream raw materials:

orotic acid

6-trichloromethyl-1H-pyrimidine-2,4-dione

6-Methyluracil

Downstream raw materials:

dipyridamole

5-nitroorotic acid

5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid

2,4,6,8-tetrahydroxypyrimidine-[5,4-d]pyrimidine

Refernces

• 1、 -. "Production method of dipyridamole bulk drug". Paragraph 0005; 0017. . Retrieved 2018/06/04.
• 2、 -. "Process for preparing orotic acid". . . Retrieved 2008/06/13.