Prazosin hydrochloride

Base Information

• Chemical Name: Prazosin hydrochloride
• CAS No.: 19237-84-4
• Molecular Formula: C19H21N5O4^.HCl
• Molecular Weight: 419.868
• Hs Code.: 2934990002
• Metabolomics Workbench ID: 53376
• Mol file: 19237-84-4.mol

Synonyms:Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-,monohydrochloride (9CI);2-[4-(2-Furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazolinehydrochloride;Adversuten;Adverszuten;Alpress LP;CP 12299-1;Deprazolin;Duramipress;Hypovase;Hypovasole;Minipress;NSC 292810;Pratsiol;Sinetens;

Chemical Property of Prazosin hydrochloride

Chemical Property:

• Appearance/Colour: off-white to yellow powder
• Vapor Pressure: 3.4E-16mmHg at 25°C
• Melting Point: 277 - 280 °C
• Boiling Point: 638.4 °C at 760 mmHg
• Flash Point: 339.9 °C
• PSA: 106.95000
• LogP: 3.17070
• Storage Temp.: Store at RT
• Solubility.: H2O: 1 mg/mL, clear, colorless
• Water Solubility.: Soluble in dimethyl sulfoxide, ethanol, water, methanol.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 4
• Exact Mass: 419.1360319
• Heavy Atom Count: 29
• Complexity: 544

Purity/Quality:

97.0%~103.0%, ^*data from raw suppliers

Prazosin Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38-62
• Safety Statements: 28-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [H+].COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.[Cl-]
• Uses: Prazosin Hydrochloride (Terazosin EP Impurity K) is an antihypertensive. α1-Adrenergic blocker. Prazosin hydrochloride has been used:to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in miceas an α1-adrenoceptor blocker,administered intragastrically in ratsas a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions An antihypertensive. α1-Adrenergic blocker.
• Therapeutic Function: Antihypertensive
• Clinical Use: Prazosin hydrochloride is readily absorbed, and plasmaconcentrations reach a peak about 3 hours after administration.Plasma half-life is between 2 and 3 hours. Prazosin hydrochlorideis highly bound to plasma protein; it does notcause adverse reactions, however, with drugs that might bedisplaced from their protein-binding sites (e.g., cardiac glycosides).It may cause severe orthostatic hypertension becauseof its -adrenergic blocking action, which preventsthe reflex venous constriction that is activated when an individualsits up from a prone position.

Technology Process of Prazosin hydrochloride

There total 6 articles about Prazosin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Methyl N-(3,4-Dimethoxy-6-cyanophenyl)-<4-(2-furoyl)piperazin-1-yl>thioformamidate (67817-59-8) → prazosin hydrochloride (19237-84-4)

Guidance literature:

With ammonium chloride; In formamide; at 120 ℃; for 20h;

DOI:10.1002/jhet.5570170436

Reference yield: 84.0%

→ prazosin hydrochloride (19237-84-4)

Guidance literature:

Reference yield:

2-furancarbonyl chloride (527-69-5) + i-Amyl alcohol (123-51-3) + 4-amino-6,7-dimethoxy-2-piperazin-1-ylquinazoline (60547-97-9) → prazosin hydrochloride (19237-84-4)

Guidance literature:

In chloroform; water;

upstream raw materials:

Methyl N-(3,4-Dimethoxy-6-cyanophenyl)-<4-(2-furoyl)piperazin-1-yl>thioformamidate

2-amino-4,5-dimethoxybenzonitrile

2-isothiocyanato-4,5-dimethoxybenzonitrile

3,4-Dimethoxy-6-<4-(2-furoyl)piperazin-1-ylthiocarbamido>benzonitrile

Downstream raw materials:

terazosin

Refernces

• 1、 -. "Cyanocarboxamidines and quinazoline process". . . Retrieved 2008/06/13.