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Naltrexone hydrochloride

Base Information Edit
  • Chemical Name:Naltrexone hydrochloride
  • CAS No.:16676-29-2
  • Molecular Formula:C20H23NO4.HCl
  • Molecular Weight:377.868
  • Hs Code.:
  • European Community (EC) Number:240-723-0
  • UNII:Z6375YW9SF
  • DSSTox Substance ID:DTXSID50937236
  • Wikidata:Q27096434
  • NCI Thesaurus Code:C679
  • RXCUI:105069
  • ChEMBL ID:CHEMBL1201149
  • Mol file:16676-29-2.mol
Naltrexone hydrochloride

Synonyms:Antaxone;Celupan;EN 1639A;EN-1639A;EN1639A;Nalorex;Naltrexone;Naltrexone Hydrochloride;Nemexin;ReVia;Trexan

Suppliers and Price of Naltrexone hydrochloride
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Naltrexone hydrochloride
  • 100mg
  • $ 339.00
  • TRC
  • Naltrexone hydrochloride
  • 50mg
  • $ 45.00
  • Tocris
  • Naltrexone hydrochloride ≥99%(HPLC)
  • 100
  • $ 102.00
  • TCI Chemical
  • Naltrexone Hydrochloride
  • 250MG
  • $ 135.00
  • TCI Chemical
  • Naltrexone Hydrochloride
  • 1G
  • $ 403.00
  • Sigma-Aldrich
  • Naltrexone hydrochloride European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Naltrexone hydrochloride European Pharmacopoeia (EP) Reference Standard
  • y0000400
  • $ 190.00
  • Sigma-Aldrich
  • Naltrexone hydrochloride
  • 250mg
  • $ 176.00
  • Sigma-Aldrich
  • Naltrexone hydrochloride
  • 1g
  • $ 530.00
  • Sigma-Aldrich
  • Naltrexone hydrochloride
  • 100mg
  • $ 87.50
Total 151 raw suppliers
Chemical Property of Naltrexone hydrochloride Edit
Chemical Property:
  • Appearance/Colour:white crystalline powder 
  • Vapor Pressure:2.71E-13mmHg at 25°C 
  • Melting Point:274-276 °C 
  • Boiling Point:558.1 °C at 760 mmHg 
  • Flash Point:291.4 °C 
  • PSA:70.00000 
  • Density:1.47 g/cm3 
  • LogP:2.26530 
  • Storage Temp.:2-8°C 
  • Sensitive.:Light Sensitive 
  • Solubility.:H2O: 50 mg/mL, clear, colorless 
  • Water Solubility.:Soluble in water at 50mg/ml. 
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:5
  • Rotatable Bond Count:2
  • Exact Mass:377.1393859
  • Heavy Atom Count:26
  • Complexity:621
Purity/Quality:

99%, *data from raw suppliers

Naltrexone hydrochloride *data from reagent suppliers

Safty Information:
  • Pictogram(s): HarmfulXn 
  • Hazard Codes:Xn 
  • Statements: 22 
  • Safety Statements: 22-36 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:C1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)O.Cl
  • Isomeric SMILES:C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O.Cl
  • Recent ClinicalTrials:Harm Reduction With Pharmacotherapy (HaRP)
  • Recent EU Clinical Trials:To evaluate the effect of low-dose naltrexone (LDN) on pain perception and quality of life in women
  • Description Naltrexone hydrochloride is a potent, long-acting, orally-effective narcotic antagonist useful in the management of narcotic addiction.
  • Uses Nonselective opioid receptor antagonist; congener of naloxone Naltrexone hydrochloride has been used:as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model.to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model.in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22. sulfonamide, carbonic anhydrase inhibitor, anti-glaucoma agent Narcotic antagonist, In treatment of?alcoholism
  • Clinical Use Opioid antagonist: Adjunctive prophylactic treatment in patient’s previously opioid dependant Treatment of alcohol dependence
  • Drug interactions Potentially hazardous interactions with other drugs Opioids: Avoid concomitant use.
Technology Process of Naltrexone hydrochloride

There total 10 articles about Naltrexone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With hydrogen; palladium on activated charcoal; platinum on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; at 50 ℃; for 2h; under 2068.65 Torr; Product distribution / selectivity;
Guidance literature:
noroxymorphone; Cyclopropanecarboxaldehyde; With hydrogen; platinum on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; at 50 ℃; for 1h; under 2068.65 Torr;
With hydrogenchloride; In ethanol; water; pH=< 4; Product distribution / selectivity;
Guidance literature:
With hydrogenchloride; In water; acetonitrile;
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