(2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 3,5-difluoro-4-hydrazinylbenzenesulfonate

Base Information

• Chemical Name: (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 3,5-difluoro-4-hydrazinylbenzenesulfonate
• CAS No.: 1335107-42-0
• Molecular Formula: C₁₄H₂₀F₂N₂O₅S
• Molecular Weight: 366.386
• Mol file: 1335107-42-0.mol

Synonyms:(2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 3,5-difluoro-4-hydrazinylbenzenesulfonate

Chemical Property of (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 3,5-difluoro-4-hydrazinylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 3,5-difluoro-4-hydrazinylbenzenesulfonate

There total 3 articles about (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 3,5-difluoro-4-hydrazinylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 3,4,5-trifluorobenzenesulfonate (1335107-39-5) → (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 3,5-difluoro-4-hydrazinylbenzenesulfonate (1335107-42-0)

Guidance literature:

With potassium carbonate; hydrazine hydrate; In acetonitrile; at 20 ℃;

DOI:10.1021/ja207004v

Reference yield:

5-hydroxymethyl-2,2,5-trimethyl-1,3-dioxane (3663-46-5) → (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 3,5-difluoro-4-hydrazinylbenzenesulfonate (1335107-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 h / 20 °C

2: potassium carbonate; hydrazine hydrate / acetonitrile / 20 °C

With potassium carbonate; hydrazine hydrate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/ja207004v

Reference yield:

3,4,5-trifluorobenzene-1-sulfonyl chloride (351003-43-5) → (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 3,5-difluoro-4-hydrazinylbenzenesulfonate (1335107-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 h / 20 °C

2: potassium carbonate; hydrazine hydrate / acetonitrile / 20 °C

With potassium carbonate; hydrazine hydrate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/ja207004v

upstream raw materials:

3,4,5-trifluorobenzene-1-sulfonyl chloride

5-hydroxymethyl-2,2,5-trimethyl-1,3-dioxane

(2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 3,4,5-trifluorobenzenesulfonate

Refernces