Benzenepropanoic acid, 4-Methyl-, Methyl ester

Base Information

• Chemical Name: Benzenepropanoic acid, 4-Methyl-, Methyl ester
• CAS No.: 56955-36-3
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.231
• Hs Code.: 2916399090
• Mol file: 56955-36-3.mol

Synonyms:methyl 3-(p-tolyl)propionate

Chemical Property of Benzenepropanoic acid, 4-Methyl-, Methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-Methyl-benzenepropanoicacidmethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, 4-Methyl-, Methyl ester

There total 27 articles about Benzenepropanoic acid, 4-Methyl-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanol (67-56-1) + 3-(4-Methylphenyl)propanoic acid (1505-50-6) → methyl 3-(p-tolyl)propionate (56955-36-3)

Guidance literature:

With chloro-trimethyl-silane; at 20 ℃;

DOI:10.1021/ja511014w

Reference yield: 95.0%

methyl 3-(4-methylphenyl)acrylate (7560-43-2,20754-20-5,50363-84-3) → methyl 3-(p-tolyl)propionate (56955-36-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1 - 2h;

Reference yield: 95.0%

3-p-tolyl-acrylic acid methyl ester (20754-20-5) → methyl 3-(p-tolyl)propionate (56955-36-3)

Guidance literature:

With maghemite-palladium nanocomposite; hydrogen; In ethanol; at 70 ℃; for 0.0125h;

DOI:10.1039/c5cy00956a

upstream raw materials:

3-p-tolyl-acrylic acid methyl ester

para-bromotoluene

methyl 3-(trifluorosilyl)propanoate

4-tolyl iodide

Downstream raw materials:

3-(4-Methylphenyl)propanoic acid

1-(3-chloropropyl)-4-methylbenzene

N-<γ-(4-Methyl-phenyl)-propyl>-propylamin

N-<γ-(4-Methyl-phenyl)-propyl>-dipropylamin

Refernces

• 1、 Topf, Christoph,Vielhaber, Thomas. "Manganese-catalyzed homogeneous hydrogenation of ketones and conjugate reduction of α,β-unsaturated carboxylic acid derivatives: A chemoselective, robust, and phosphine-free in situ-protocol". . . Retrieved 2021/07/10.
• 2、 Wei, Kaijie,Yang, Tonghao,Chen, Qing,Liang, Siyu,Yu, Wei. "Iron-catalysed 1,2-aryl migration of tertiary azides". supporting information. p. 11685 - 11688. Retrieved 2020/10/19.