methyl 6-chloro-2-(3-fluorophenethylamino)nicotinate

Base Information

• Chemical Name: methyl 6-chloro-2-(3-fluorophenethylamino)nicotinate
• CAS No.: 1005756-36-4
• Molecular Formula: C₁₅H₁₄ClFN₂O₂
• Molecular Weight: 308.74
• Mol file: 1005756-36-4.mol

Synonyms:methyl 6-chloro-2-(3-fluorophenethylamino)nicotinate

Chemical Property of methyl 6-chloro-2-(3-fluorophenethylamino)nicotinate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 6-chloro-2-(3-fluorophenethylamino)nicotinate

There total 2 articles about methyl 6-chloro-2-(3-fluorophenethylamino)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-(3-Fluorophenyl)ethylamine (404-70-6) + methyl 2,6-dichloronicotinate (65515-28-8) → methyl 6-chloro-2-(3-fluorophenethylamino)nicotinate (1005756-36-4)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 10h;

Reference yield:

2,6-dichloropyridine-3-carboxylic acid (38496-18-3) → methyl 6-chloro-2-(3-fluorophenethylamino)nicotinate (1005756-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / Heating / reflux

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 10 h / 100 °C

With thionyl chloride; potassium carbonate; In 1-methyl-pyrrolidin-2-one;

Reference yield: 100.0%

methyl 6-chloro-2-(3-fluorophenethylamino)nicotinate (1005756-36-4) → 6-chloro-2-(3-fluorophenethylamino)nicotinic acid (1005756-49-9)

Guidance literature:

methyl 6-chloro-2-(3-fluorophenethylamino)nicotinate; With sodium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 48h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=3;

upstream raw materials:

2-(3-Fluorophenyl)ethylamine

methyl 2,6-dichloronicotinate

2,6-dichloropyridine-3-carboxylic acid

Downstream raw materials:

6-chloro-2-(3-fluorophenethylamino)nicotinic acid

2-(3-fluorophenethylamino)-6-(1H-pyrazol-4-yl)nicotinic acid

6-(2-cyanophenyl)-2-(3-fluorophenethylamino)nicotinic acid

Refernces