4-aminobenzenesulfonohydrazide

Base Information

• Chemical Name: 4-aminobenzenesulfonohydrazide
• CAS No.: 5450-86-2
• Molecular Formula: C6H9N3O2S
• Molecular Weight: 187.222
• Hs Code.: 2935009090
• Mol file: 5450-86-2.mol

Synonyms:Sulfanilic acid hydrazide;

Chemical Property of 4-aminobenzenesulfonohydrazide

Chemical Property:

• Vapor Pressure: 4.52E-07mmHg at 25°C
• Refractive Index: 1.636
• Boiling Point: 414.2 °C at 760 mmHg
• Flash Point: 204.3 °C
• PSA: 106.59000
• Density: 1.445 g/cm³
• LogP: 2.17400

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-aminobenzenesulfonohydrazide

There total 8 articles about 4-aminobenzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-acetamidobenzenesulfonylhydrazine (3989-50-2) → para-aminophenylsulfonyl hydrazide (5450-86-2)

Guidance literature:

With hydrogenchloride;

DOI:10.1039/jr9420000737

Reference yield:

p-acetylaminobenzenesulfonyl chloride (121-60-8) → para-aminophenylsulfonyl hydrazide (5450-86-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate; water; hydrazine dihydrochloride

2: pyridine

3: aqueous hydrochloric acid

With pyridine; hydrogenchloride; hydrazine dihydrochloride; water; sodium carbonate;

DOI:10.1021/ja01183a056

Reference yield:

N-acetyl-N'-(N-acetyl-sulfanilyl)-hydrazine (80414-97-7) → para-aminophenylsulfonyl hydrazide (5450-86-2)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01183a056

upstream raw materials:

N-acetyl-N'-(N-acetyl-sulfanilyl)-hydrazine

4-aminobenzenesulfonyl chloride

N'N'-diacetyl p-acetamidobenzenesulfonohydrazide

4-acetamidobenzenesulfonylhydrazine

Downstream raw materials:

sulfanilic acid-(1,3-dimethyl-but-2-enylidenehydrazide)

sulfanilic acid-(β,β,β-trifluoro-isopropylidenehydrazide)

sulfanilic acid cyclohexylidenehydrazide

4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide

Refernces

• 1、 More, Uttam A.,Joshi, Shrinivas D.,Aminabhavi, Tejraj M.,Gadad, Andanappa K.,Nadagouda, Mallikarjuna N.,Kulkarni, Venkatrao H.. "Design, synthesis, molecular docking and 3D-QSAR studies of potent inhibitors of enoyl-acyl carrier protein reductase as potential antimycobacterial agents". . p. 199 - 218. Retrieved 2014/01/06.