3-Chloro-1,1,1-trifluoro-3-phenylpropane

Base Information

• Chemical Name: 3-Chloro-1,1,1-trifluoro-3-phenylpropane
• CAS No.: 126488-91-3
• Molecular Formula: C₉H₈ClF₃
• Molecular Weight: 208.611
• Mol file: 126488-91-3.mol

Synonyms:3-Chloro-1,1,1-trifluoro-3-phenylpropane

Chemical Property of 3-Chloro-1,1,1-trifluoro-3-phenylpropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Chloro-1,1,1-trifluoro-3-phenylpropane

There total 6 articles about 3-Chloro-1,1,1-trifluoro-3-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + trifluoromethane sulfonyl chloride (421-83-0) → 3-Chloro-1,1,1-trifluoro-3-phenylpropane (126488-91-3)

Guidance literature:

tris(triphenylphosphine)ruthenium(II) chloride; In benzene; at 120 ℃; for 16h; sealed tube;

DOI:10.1039/c39890001559

Reference yield: 82.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + trifluoromethane sulfonyl chloride (421-83-0) → 3-Chloro-1,1,1-trifluoro-3-phenylpropane (126488-91-3) + 1-((E)-2-((trifluoromethyl)sulfonyl)vinyl)benzene (947-24-0)

Guidance literature:

With C₅₉H₅₂CuN₂OP₂⁽¹⁺⁾*F₆P^(1-); potassium carbonate; In dichloromethane; at 40 ℃; for 3h; Reagent/catalyst; Temperature; Solvent; Wavelength; Catalytic behavior; Inert atmosphere; Schlenk technique; Glovebox; Irradiation;

DOI:10.1021/acs.organomet.8b00585

Reference yield: 81.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + Langlois reagent (2926-29-6) → 3-Chloro-1,1,1-trifluoro-3-phenylpropane (126488-91-3)

Guidance literature:

With iron(III) chloride; dipotassium peroxodisulfate; In acetonitrile; at 80 ℃; for 10h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior; Schlenk technique; Glovebox; Sealed tube; Inert atmosphere;

DOI:10.1002/cjoc.201500641

upstream raw materials:

styrene

trifluoromethane sulfonyl chloride

Langlois reagent

2-(trifluoromethylsulfonyl)-N-tert-butoxycarbonylhydrazine

Downstream raw materials:

(E)-3,3,3-trifluoro-1-phenylpropene

(3,3,3-trifluoropropyl)benzene

Refernces

• 1、 Guo, Jing-Yu,Wu, Ruo-Xin,Jin, Ji-Kang,Tian, Shi-Kai. "TfNHNHBoc as a Trifluoromethylating Agent for Vicinal Difunctionalization of Terminal Alkenes". . p. 3850 - 3853. Retrieved 2016.
• 2、 Alkan-Zambada, Murat,Hu, Xile. "Cu Photoredox Catalysts Supported by a 4,6-Disubstituted 2,2′-Bipyridine Ligand: Application in Chlorotrifluoromethylation of Alkenes". supporting information. p. 3928 - 3935. Retrieved 2018/10/24.