6-METHYLPREGNENOLONE

Base Information

• Chemical Name: 6-METHYLPREGNENOLONE
• CAS No.: 6222-82-8
• Molecular Formula: C24H36 O3
• Molecular Weight: 330.5
• Mol file: 6222-82-8.mol

Synonyms:Pregn-5-en-20-one,3b-hydroxy-6-methyl-, acetate(6CI,7CI,8CI); 3b-Acetoxy-6-methylpregn-5-en-20-one;NSC 152215

Chemical Property of 6-METHYLPREGNENOLONE

Chemical Property:

• Vapor Pressure: 1.34E-08mmHg at 25°C
• Boiling Point: 458.8°C at 760 mmHg
• Flash Point: 195.7°C
• PSA: 43.37000
• Density: 1.08g/cm³
• LogP: 5.47620

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHYLPREGNENOLONE

There total 4 articles about 6-METHYLPREGNENOLONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β-acetoxy-6-methyl-pregna-5,16-dien-20-one (20867-46-3) → 3β-acetoxy-6-methylpregn-5-en-20-one (6222-82-8)

Guidance literature:

With methanol; Lindlar's catalyst; Hydrogenation;

Reference yield:

(25R)-6-methyl-furosta-5,20(22)-diene-3β,26-diol (118924-71-3) → 3β-acetoxy-6-methylpregn-5-en-20-one (6222-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Behandeln des Reaktionsprodukts mit CrO₃ in Essigsaeure bei Raumtemperatur und anschliessend mit Essigsaeure bei Siedetemperatur

2: palladium/CaCO₃; methanol / Hydrogenation

With pyridine; methanol; Lindlar's catalyst;

Reference yield:

Acetic acid (3S,5S,6R,8R,9S,10R,13S,14S,17S)-6-hydroxy-6,10,13-trimethyl-17-(2-methyl-[1,3]dioxolan-2-yl)-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester (40552-03-2) → 3β-acetoxy-6-methylpregn-5-en-20-one (6222-82-8)

Guidance literature:

Multistep reaction; (i) SOCl₂, Py, (ii) TsOH, H₂O, acetone;

upstream raw materials:

3β-acetoxy-6-methyl-pregna-5,16-dien-20-one

Acetic acid (3S,5S,6R,8R,9S,10R,13S,14S,17S)-6-hydroxy-6,10,13-trimethyl-17-(2-methyl-[1,3]dioxolan-2-yl)-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

(25R)-6-methyl-furosta-5,20(22)-diene-3β,26-diol

Downstream raw materials:

6α-methyl-pregn-4-ene-3,20-dione

3β-hydroxy-6-methylpregn-5-en-20-one