Technology Process of (12aS)-2,3,12,12a-Tetrahydro1-methyl-6,9-dimethoxy-1H-[1]benzooxepino[2,3,4-ij]isoquinoline-10-ol
There total 38 articles about (12aS)-2,3,12,12a-Tetrahydro1-methyl-6,9-dimethoxy-1H-[1]benzooxepino[2,3,4-ij]isoquinoline-10-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(1R,2S,5R)-(+)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl chloroacetate; 2,12-dihydro-6,9-dimethoxy-3H-[1]benzoxepino[2,3,4-ij]isoquinolin-10-ol;
In
methanol;
for 10h;
With
sodium tetrahydroborate;
In
methanol;
at 0 - 20 ℃;
DOI:10.1021/jo030287t
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaNO2; H2SO4
1.2: 83 percent / NaN3 / 0.5 h / 0 °C
2.1: 41.31 mg / TFMSA / CCl4 / 10 h / -5 °C
3.1: sodium nitrite; sulfuric acid / H2O / 1 h / 0 °C
3.2: water / 2 h / 60 °C
4.1: methanol / 10 h
4.2: 95 percent / sodium borohydride / methanol / 0 - 20 °C
With
trifluorormethanesulfonic acid; sulfuric acid; sodium nitrite;
In
methanol; tetrachloromethane; water;
DOI:10.1021/jo030287t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 41.31 mg / TFMSA / CCl4 / 10 h / -5 °C
2.1: sodium nitrite; sulfuric acid / H2O / 1 h / 0 °C
2.2: water / 2 h / 60 °C
3.1: methanol / 10 h
3.2: 95 percent / sodium borohydride / methanol / 0 - 20 °C
With
trifluorormethanesulfonic acid; sulfuric acid; sodium nitrite;
In
methanol; tetrachloromethane; water;
DOI:10.1021/jo030287t