2-PropanaMine, N-(2-chloroethyl)-, hydrochloride

Base Information

• Chemical Name: 2-PropanaMine, N-(2-chloroethyl)-, hydrochloride
• CAS No.: 6306-61-2
• Molecular Formula: C5H12ClN
• Molecular Weight: 158.071
• Hs Code.: 2921199990
• Mol file: 6306-61-2.mol

Synonyms:N-(2-chloroethyl)propan-2-amine,hydrochloride;

Chemical Property of 2-PropanaMine, N-(2-chloroethyl)-, hydrochloride

Chemical Property:

• Vapor Pressure: 5.79mmHg at 25°C
• Melting Point: 180-181 °C
• Boiling Point: 141.7°C at 760 mmHg
• Flash Point: 39.5°C
• PSA: 12.03000
• Density: 0.923g/cm³
• LogP: 2.41610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

N-(2-Chloroethyl)propan-2-aminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PropanaMine, N-(2-chloroethyl)-, hydrochloride

There total 1 articles about 2-PropanaMine, N-(2-chloroethyl)-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

i-propyl(2-(hydroxy)ethyl)amine (109-56-8) → N-(2-chloroethyl)-N-isopropylamine hydrochloride (6306-61-2)

Guidance literature:

With thionyl chloride; In chloroform; for 6h; Heating;

DOI:10.1248/cpb.50.941

Reference yield: 81.5%

N-(3,5-dimethoxyphenyl)-3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinamine (1346133-39-8) + N-(2-chloroethyl)-N-isopropylamine hydrochloride (6306-61-2) → N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine (1346242-81-6)

Guidance literature:

N‐(3,5‐dimethoxyphenyl)‐3‐(1‐methyl‐1H‐pyrazol‐4‐yl)quinoxalin‐6‐amine; With tetrabutylammomium bromide; potassium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 2h; Inert atmosphere;

N-(2-chloroethyl)-N-isopropylamine hydrochloride; In tetrahydrofuran; water; at 55 ℃; for 6h;

Reference yield: 80.0%

N-(2-chloroethyl)-N-isopropylamine hydrochloride (6306-61-2) + C20H19N5O3 → 7-((3,5-dimethoxyphenyl)(2-(isopropylamino)ethyl)amino)-3-(1-methyl-1H-pyrazol-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:

C₂₀H₁₉N₅O₃; With tetrabutylammomium bromide; potassium hydroxide; In 2-methyltetrahydrofuran; water; at 50 ℃; for 1h;

N-(2-chloroethyl)-N-isopropylamine hydrochloride; In 2-methyltetrahydrofuran; water; at 50 ℃; for 18h;

DOI:10.1016/j.ejmech.2021.113499

upstream raw materials:

i-propyl(2-(hydroxy)ethyl)amine

Downstream raw materials:

Benzilsaeure-<2-isopropylamino-aethylester>

N-isopropyl-N'-phenylethylenediamine

6-amino-1-isopropyl-4-methylhexahydro-1,4-diazepine

1-ethyl-4-isopropyl-6-nitrohexahydro-1,4-diazepine

Refernces