Technology Process of 4-chloro-3-[(7-methoxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-3-carbonyl)-amino]-benzoic acid methyl ester
There total 10 articles about 4-chloro-3-[(7-methoxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-3-carbonyl)-amino]-benzoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: triethylamine; trichlorophosphate / 2 h / 0 - 120 °C
2.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C
3.1: dimethyl sulfoxide / 3 h / 135 °C
3.2: pH 3 - 4
4.1: sulfuric acid / 4 h / 20 °C
4.2: 0 °C / Reflux
4.3: 0 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 10 - 20 °C / Inert atmosphere
5.2: 0.33 h / 0 - 20 °C
6.1: manganese(IV) oxide / tetrahydrofuran / 20 °C / Inert atmosphere
7.1: piperidine / acetic acid / methanol / 18 h / 60 °C / Inert atmosphere
8.1: sodium hydroxide; water / methanol / 18 h / 65 °C
8.2: pH 3 - 4
9.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C
With
piperidine; manganese(IV) oxide; lithium aluminium tetrahydride; sulfuric acid; water; triethylamine; HATU; sodium hydroxide; trichlorophosphate;
acetic acid;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C
2.1: dimethyl sulfoxide / 3 h / 135 °C
2.2: pH 3 - 4
3.1: sulfuric acid / 4 h / 20 °C
3.2: 0 °C / Reflux
3.3: 0 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 10 - 20 °C / Inert atmosphere
4.2: 0.33 h / 0 - 20 °C
5.1: manganese(IV) oxide / tetrahydrofuran / 20 °C / Inert atmosphere
6.1: piperidine / acetic acid / methanol / 18 h / 60 °C / Inert atmosphere
7.1: sodium hydroxide; water / methanol / 18 h / 65 °C
7.2: pH 3 - 4
8.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C
With
piperidine; manganese(IV) oxide; lithium aluminium tetrahydride; sulfuric acid; water; triethylamine; HATU; sodium hydroxide;
acetic acid;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;