trans-4-chlorocyclohexane carboxylic acid

Base Information

• Chemical Name: trans-4-chlorocyclohexane carboxylic acid
• CAS No.: 56447-20-2
• Molecular Formula: C₇H₁₁ClO₂
• Molecular Weight: 162.616
• Mol file: 56447-20-2.mol

Synonyms:trans-4-chlorocyclohexane carboxylic acid

Chemical Property of trans-4-chlorocyclohexane carboxylic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of trans-4-chlorocyclohexane carboxylic acid

There total 4 articles about trans-4-chlorocyclohexane carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

cyclohexylcarboxamide (1122-56-1) → methyl cyclohexylcarboxylate (4630-82-4) + trans-4-chlorocyclohexane carboxylic acid (56447-20-2) + 2-oxa-bicyclo[2.2.2]octan-3-one (4350-84-9) + 3-Chloro-cyclohexanecarboxylic acid methyl ester

Guidance literature:

With sodium persulfate; In water; at 85 - 90 ℃; for 10h; Yields of byproduct given;

DOI:10.1007/BF00957713

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + cyclohexylcarboxamide (1122-56-1) → methyl cyclohexylcarboxylate (4630-82-4) + trans-4-chlorocyclohexane carboxylic acid (56447-20-2) + 2-oxa-bicyclo[2.2.2]octan-3-one (4350-84-9) + 3-Chloro-cyclohexanecarboxylic acid methyl ester

Guidance literature:

With sodium persulfate; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts; 1.) H₂O, 85 deg C to 90 deg C, 10 h;

DOI:10.1007/BF00957713

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + cyclohexylcarboxamide (1122-56-1) → trans-4-chlorocyclohexane carboxylic acid (56447-20-2) + 2-oxa-bicyclo[2.2.2]octan-3-one (4350-84-9) + 3-Chloro-cyclohexanecarboxylic acid methyl ester + 2-chlorocyclohexanecarboxylic acid methyl ester

Guidance literature:

With sodium persulfate; copper dichloride; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given; 1.) 85 deg C to 90 deg C, 10 h;

DOI:10.1007/BF00957713

upstream raw materials:

diazomethane

cyclohexylcarboxamide

Downstream raw materials:

4-chloro-1-cyclohexanecarboxylic acid chloride

2-(trans-4-chlorocyclohexyl)-1,1,2-trifluoroethylene

Refernces