(R)-(-)-N-<5-Chlor-2-nitro-phenyl>-N-methyl-ethyl-methyl-cyanessigsaeureamid

Base Information

• Chemical Name: (R)-(-)-N-<5-Chlor-2-nitro-phenyl>-N-methyl-ethyl-methyl-cyanessigsaeureamid
• CAS No.: 154334-39-1
• Molecular Formula: C₁₃H₁₄ClN₃O₃
• Molecular Weight: 295.725
• Mol file: 154334-39-1.mol

Synonyms:(R)-(-)-N-<5-Chlor-2-nitro-phenyl>-N-methyl-ethyl-methyl-cyanessigsaeureamid

Chemical Property of (R)-(-)-N-<5-Chlor-2-nitro-phenyl>-N-methyl-ethyl-methyl-cyanessigsaeureamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-N-<5-Chlor-2-nitro-phenyl>-N-methyl-ethyl-methyl-cyanessigsaeureamid

There total 1 articles about (R)-(-)-N-<5-Chlor-2-nitro-phenyl>-N-methyl-ethyl-methyl-cyanessigsaeureamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-chloro-2-methylaminonitrobenzene (35966-84-8) + (R)-(+)-Ethylmethylcyanessigsaeurechlorid → (R)-(-)-N-<5-Chlor-2-nitro-phenyl>-N-methyl-ethyl-methyl-cyanessigsaeureamid (154334-39-1)

Guidance literature:

In pyridine; Heating;

DOI:10.1002/ardp.19933260911

Reference yield: 88.0%

(R)-(-)-N-<5-Chlor-2-nitro-phenyl>-N-methyl-ethyl-methyl-cyanessigsaeureamid (154334-39-1) → (R)-(-)-N-<5-Chlor-2-nitro-phenyl>-N-methyl-ethyl-methyl-malonsaeurediamid (154003-67-5)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In methanol;

DOI:10.1002/ardp.19933260911

Reference yield:

(R)-(-)-N-<5-Chlor-2-nitro-phenyl>-N-methyl-ethyl-methyl-cyanessigsaeureamid (154334-39-1) → (S)-(+)-8-Chlor-3-ethyl-1,3-dimethyl-5-phenyl-1H-1,5-benzodiazepin(3H,5H)-2,4-dion

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / 30percent H₂O₂, 0.5N NaOH / methanol

2: 55 percent / Zn-powder / aq. HCl / 26 h / Ambient temperature

3: 97 percent / kaliumacetate, Cu-powder / 6 h / 150 °C

With sodium hydroxide; dihydrogen peroxide; potassium acetate; copper; zinc; In hydrogenchloride; methanol;

DOI:10.1002/ardp.19933260911

upstream raw materials:

4-chloro-2-methylaminonitrobenzene

Downstream raw materials:

(R)-(-)-N-<5-Chlor-2-nitro-phenyl>-N-methyl-ethyl-methyl-malonsaeurediamid

Refernces