C₂₁H₂₃ClF₄N₆O₂

Base Information

• Chemical Name: C₂₁H₂₃ClF₄N₆O₂
• CAS No.: 1510832-36-6
• Molecular Formula: C₂₁H₂₃ClF₄N₆O₂
• Molecular Weight: 502.899
• Mol file: 1510832-36-6.mol

Synonyms:C₂₁H₂₃ClF₄N₆O₂

Chemical Property of C₂₁H₂₃ClF₄N₆O₂

Chemical Property:

Purity/Quality:

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Technology Process of C₂₁H₂₃ClF₄N₆O₂

There total 31 articles about C₂₁H₂₃ClF₄N₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.3%

6-chloro-5-fluoropyrimidin-4-ylamine (851984-15-1) + (3R,3‘S,4‘S)-3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4’-hydroxy-[1,3’-bipiperidin]-2-one hydrochloride (1510832-33-3) → C21H23ClF4N6O2 (1510832-36-6)

Guidance literature:

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In propan-1-ol; at 100 ℃; for 36h;

Reference yield:

ethyl (R)-2-pyrrolidone-5-carboxylate (68766-96-1) → C21H23ClF4N6O2 (1510832-36-6)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 40 °C / Inert atmosphere

2: diisobutylaluminium hydride / 2-methyltetrahydrofuran; n-heptane / -45 - -35 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride / dimethyl sulfoxide / 2 h / 50 °C

4: ethanol / 75 °C

With copper(l) iodide; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; caesium carbonate; N,N`-dimethylethylenediamine; In 2-methyltetrahydrofuran; 1,4-dioxane; ethanol; n-heptane; dimethyl sulfoxide;

Reference yield:

C23H29ClF4N6O3 (1510832-70-8) → C21H23ClF4N6O2 (1510832-36-6)

Guidance literature:

In ethanol; at 75 ℃;

upstream raw materials:

C₂₄H₃₅ClF₃N₃O₅

(3S,4S)-3-aminopiperidin-4-ol

tert-butyl (3S,4S)-3-amino-4-hydroxypiperidine-1-carboxylate

ethyl (R)-2-pyrrolidone-5-carboxylate

Refernces