2-aminobutyric acid methyl ester

Base Information

• Chemical Name: 2-aminobutyric acid methyl ester
• CAS No.: 2483-62-7
• Molecular Formula: C5H11 N O2
• Molecular Weight: 117.148
• Hs Code.: 2922499990
• Mol file: 2483-62-7.mol

Synonyms:Butanoicacid, 2-amino-, methyl ester, (?à)-; Butyric acid, 2-amino-, methyl ester, DL- (8CI); (?à)-Methyl 2-aminobutyrate; 2-Aminobutanoicacid methyl ester; DL-a-Aminobutyric acid methyl ester; Methyl (?à)-2-aminobutanoate; Methyl 2-amino-4-butenoate; Methyl2-aminobutanoate; Methyl 2-aminobutyrate; Methyl DL-2-aminobutyrate; Methyl a-aminobutyrate

Chemical Property of 2-aminobutyric acid methyl ester

Chemical Property:

• Vapor Pressure: 11mmHg at 25°C
• Boiling Point: 127.8°Cat760mmHg
• Flash Point: 3.5°C
• PSA: 52.32000
• Density: 0.987g/cm³
• LogP: 0.59700

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-aminobutyric acid methyl ester

There total 13 articles about 2-aminobutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

methanol (67-56-1) + L-2-aminobutyric acid (1492-24-6) → (S)-2-aminobutyric acid methyl ester (2483-62-7,15399-11-8,15399-22-1,74645-03-7)

Guidance literature:

With thionyl chloride; at 0 ℃; for 2h; Inert atmosphere; Reflux;

Reference yield: 81.0%

N-benzyloxycarbonyl-L-α-vinylglycine methyl ester (75266-40-9) → (S)-2-aminobutyric acid methyl ester (2483-62-7,15399-11-8,15399-22-1,74645-03-7)

Guidance literature:

With hydrogen; Pd-BaSO₄; In methanol; for 0.75h;

DOI:10.1021/jo01312a002

Reference yield: 64.0%

(S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride (2491-18-1) → (S)-2-aminobutyric acid methyl ester (2483-62-7,15399-11-8,15399-22-1,74645-03-7)

Guidance literature:

With Raney nickel; In water; at 60 ℃; for 4h; pH=10; pH-value;

DOI:10.1039/C8OB03088J

upstream raw materials:

aminocyclopropane-1-carboxylic acid

methyl 1-aminocyclopropane-1-carboxylate

methanol

L-2-aminobutyric acid

Downstream raw materials:

α-Z-N^ε-BOC-L-Lysyl>-L-α-amino-buttersaeure-methylester

(3S,6S)-3,6-diethylpiperazine-2,5-dione

5-Acetyl-4-phenyl-2-ethylimidazole

C₂₃H₂₁NO₈

Refernces

• 1、 Lei, Meng,Zhang, Haoyang,Miao, Hang,Du, Xiao,Zhou, Hui,Wang, Jia,Wang, Xueyuan,Feng, Huayun,Shi, Jingmiao,Liu, Zhaogang,Shen, Jian,Zhu, Yongqiang. "Preparation and biological evaluation of soluble tetrapeptide epoxyketone proteasome inhibitors". . p. 4151 - 4162. Retrieved 2019/08/07.
• 2、 -. "BET (bromodomain and extraterminal domain)/HDAC (histone deacetylase) double-target inhibitor, and preparation method and application thereof". Paragraph 0047-0049. . Retrieved 2017/09/02.