2-methyl-5(4H)-oxazolone

Base Information

• Chemical Name: 2-methyl-5(4H)-oxazolone
• CAS No.: 24474-93-9
• Molecular Formula: C4H5 N O2
• Molecular Weight: 99.09
• Hs Code.: 2934999090
• Mol file: 24474-93-9.mol

Synonyms:2-Oxazolin-5-one,2-methyl- (8CI); 2-Methyl-2-oxazolin-5-one; 2-Methyl-5(4H)-oxazolone;4,5-Dihydro-2-methyl-5-oxo-1,3-oxazole; NSC 339473

Chemical Property of 2-methyl-5(4H)-oxazolone

Chemical Property:

• Vapor Pressure: 16.2mmHg at 25°C
• Boiling Point: 119.1°C at 760 mmHg
• Flash Point: 39.3°C
• PSA: 38.66000
• Density: 1.31g/cm³
• LogP: -0.60280

Purity/Quality:

98%min ^*data from raw suppliers

2-METHYL-5(4H)-OXAZOLONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Methyl-2-oxazolin-5-one is used for a multireference configuration interaction study with singles and doubles of some mesoionic rings to determine reaction and activation free energies for the ring-?opening reaction.

Technology Process of 2-methyl-5(4H)-oxazolone

There total 3 articles about 2-methyl-5(4H)-oxazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

N-acetylglycine (543-24-8) → 2-methyl-4H-oxazol-5-one (24474-93-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane;

Reference yield:

chloroformic acid ethyl ester (541-41-3) + N-acetylglycine (543-24-8) → 2-methyl-4H-oxazol-5-one (24474-93-9)

Guidance literature:

With triethylamine; In benzene; for 0.166667h; Heating;

Reference yield:

acetic anhydride (108-24-7) + glycine (56-40-6,18875-39-3,25718-94-9) → 2-methyl-4H-oxazol-5-one (24474-93-9)

Guidance literature:

In dichloromethane;

DOI:10.1016/S0040-4039(97)10101-0

upstream raw materials:

chloroformic acid ethyl ester

N-acetylglycine

acetic anhydride

glycine

Downstream raw materials:

(Z)-2-methyl-4-(4-nitrobenzylidene)oxazol-5(4H)-one

(Z)-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate

(Z)-2-methoxy-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate

3-acetamido-6-bromo-2H-chromen-2-one

Refernces

• 1、 Goswami, Limi,Tripathy, Pradeep K.. "Synthesis of Erlenmeyer azlactones using arylsulphonyl chloride as cyclocondensing agent". . p. 281 - 282. Retrieved 2019/01/21.
• 2、 Jursic, Branko S.,Sagiraju, Sarada,Ancalade, Dustin K.,Clark, Traneil,Stevens, Edwin D.. "Practical preparation of Z-α-(N-acetylamino)- and Z-α-(N-benzoylamino)-α,β-unsaturated acids". . p. 1709 - 1714. Retrieved 2008/02/01.