N-(4-acetylphenyl)-4-chlorobenzenesulfonamide

Base Information

• Chemical Name: N-(4-acetylphenyl)-4-chlorobenzenesulfonamide
• CAS No.: 72178-38-2
• Molecular Formula: C14H12ClNO3S
• Molecular Weight: 309.773
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID30356926
• Wikidata: Q82136570
• Mol file: 72178-38-2.mol

Synonyms:N-(4-acetylphenyl)-4-chlorobenzenesulfonamide;72178-38-2;N-(4-Acetyl-phenyl)-4-chloro-benzenesulfonamide;N-(4-acetylphenyl)-4-chlorobenzene-1-sulfonamide;Benzenesulfonamide,N-(4-acetylphenyl)-4-chloro-;DTXSID30356926;STK082605;AKOS000115342;CS-0218474;EN300-01098;Z45615409

Chemical Property of N-(4-acetylphenyl)-4-chlorobenzenesulfonamide

Chemical Property:

• Vapor Pressure: 3.25E-09mmHg at 25°C
• Refractive Index: 1.621
• Boiling Point: 475.7 °C at 760 mmHg
• Flash Point: 241.5 °C
• PSA: 71.62000
• Density: 1.395 g/cm³
• LogP: 4.49720
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 309.0226421
• Heavy Atom Count: 20
• Complexity: 430

Purity/Quality:

98%Min ^*data from raw suppliers

N-(4-ACETYL-PHENYL)-4-CHLORO-BENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)Cl

Technology Process of N-(4-acetylphenyl)-4-chlorobenzenesulfonamide

There total 2 articles about N-(4-acetylphenyl)-4-chlorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

p-aminobenzophenone (99-92-3) + 4-chlorobenzenesulfonyl chloride (98-60-2) → N-(4-acetylphenyl)-4-chloro-benzenesulfonamide (72178-38-2)

Guidance literature:

p-aminobenzophenone; With pyridine; In dichloromethane; at 20 ℃; for 1h;

4-chlorobenzenesulfonyl chloride; In dichloromethane; for 10h;

Reference yield:

→ N-(4-acetylphenyl)-4-chloro-benzenesulfonamide (72178-38-2)

Guidance literature:

/BRN= 471493/, /BRN= 511583/;

Reference yield: 92.0%

N-(4-acetylphenyl)-4-chloro-benzenesulfonamide (72178-38-2) → 4-chloro-N-[4-(1-hydrazonoethyl)phenyl]benzenesulfonamide

Guidance literature:

With boron trifluoride diethyl etherate; hydrazine; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1134/S1070363216120471

upstream raw materials:

p-aminobenzophenone

4-chlorobenzenesulfonyl chloride

Downstream raw materials:

4-Chloro-N-[4-((E)-3-furan-2-yl-acryloyl)-phenyl]-benzenesulfonamide

4-Chloro-N-{4-[(E)-3-(4-chloro-phenyl)-acryloyl]-phenyl}-benzenesulfonamide

4-Chloro-N-{4-[(E)-3-(2-chloro-phenyl)-acryloyl]-phenyl}-benzenesulfonamide

4-Chloro-N-{4-[(E)-3-(3-nitro-phenyl)-acryloyl]-phenyl}-benzenesulfonamide

Refernces

• 1、 Ghorab, Mostafa M.,Ragab, Fatma A.,Heiba, Helmy I.,Soliman, Aiten M.. "Anticancer and radio-sensitizing evaluation of some new sulfonamide derivatives bearing pyridone, thiophene, and hydrazone moieties". . p. 4657 - 4681. Retrieved 2017.
• 2、 Wash, Paul L.,Hoffman, Timothy Z.,Wiley, Brandon M.,Bonnefous, Celine,Smith, Nicholas D.,Sertic, Michael S.,Lawrence, Charles M.,Symons, Kent T.,Nguyen, Phan-Manh,Lustig, Kevin D.,Guo, Xin,Annable, Tami,Noble, Stewart A.,Hager, Jeffrey H.,Hassig, Christian A.,Malecha, James W.. "α-Mercaptoketone based histone deacetylase inhibitors". scheme or table. p. 6482 - 6485. Retrieved 2009/10/01.