Technology Process of Ethyl 2-(6-amino-3-phenyl-1H-indazol-1-yl)thiazole-4-carboxylate
There total 4 articles about Ethyl 2-(6-amino-3-phenyl-1H-indazol-1-yl)thiazole-4-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C
2: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 80 °C
3: (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide; potassium phosphate; 1,3,5-trimethyl-benzene / 185 °C
4: hydrogen; palladium on activated charcoal / methanol / 20 °C
With
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; palladium on activated charcoal; hydrogen; iodine; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; tris-(o-tolyl)phosphine; potassium hydroxide; 1,3,5-trimethyl-benzene;
In
methanol; N,N-dimethyl-formamide;
2: |Suzuki-Miyaura Coupling / 3: |Buchwald Indole Synthesis;
DOI:10.1016/j.bmcl.2014.01.052
- Guidance literature:
-
Multi-step reaction with 2 steps
1: (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide; potassium phosphate; 1,3,5-trimethyl-benzene / 185 °C
2: hydrogen; palladium on activated charcoal / methanol / 20 °C
With
potassium phosphate; copper(l) iodide; palladium on activated charcoal; hydrogen; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; 1,3,5-trimethyl-benzene;
In
methanol;
1: |Buchwald Indole Synthesis;
DOI:10.1016/j.bmcl.2014.01.052