5-(benzyloxy)-4-chloro-6-methoxyquinazoline

Base Information

• Chemical Name: 5-(benzyloxy)-4-chloro-6-methoxyquinazoline
• CAS No.: 120075-53-8
• Molecular Formula: C₁₆H₁₃ClN₂O₂
• Molecular Weight: 300.744
• Mol file: 120075-53-8.mol

Synonyms:5-(benzyloxy)-4-chloro-6-methoxyquinazoline

Chemical Property of 5-(benzyloxy)-4-chloro-6-methoxyquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(benzyloxy)-4-chloro-6-methoxyquinazoline

There total 4 articles about 5-(benzyloxy)-4-chloro-6-methoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-(benzyloxy)-6-methoxyquinazolin-4(3H)-one (120075-51-6) → 5-(benzyloxy)-4-chloro-6-methoxyquinazoline (120075-53-8)

Guidance literature:

With triethylamine; trichlorophosphate; In benzene; at 80 ℃; for 3h;

DOI:10.1248/cpb.36.3933

Reference yield:

2-(benzyloxy)-3-methoxy-6-nitrobenzaldehyde (2426-61-1) → 5-(benzyloxy)-4-chloro-6-methoxyquinazoline (120075-53-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / 10percent aq. potassium permanganate / acetone / 7 h / 40 °C

2: 79 percent / FeSO₄*7H₂O, 8M NH₄OH / H₂O / 0.5 h / Heating

3: 80 percent / piperidine / ethanol / 30 h / Heating

4: 80 percent / phosphoryl chloride, triethylamine / benzene / 3 h / 80 °C

With piperidine; ammonium hydroxide; potassium permanganate; iron(II) sulfate; triethylamine; trichlorophosphate; In ethanol; water; acetone; benzene;

DOI:10.1248/cpb.36.3933

Reference yield:

6-amino-2-benzyloxy-3-methoxybenzoic acid (120075-49-2) → 5-(benzyloxy)-4-chloro-6-methoxyquinazoline (120075-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / piperidine / ethanol / 30 h / Heating

2: 80 percent / phosphoryl chloride, triethylamine / benzene / 3 h / 80 °C

With piperidine; triethylamine; trichlorophosphate; In ethanol; benzene;

DOI:10.1248/cpb.36.3933

upstream raw materials:

5-(benzyloxy)-6-methoxyquinazolin-4(3H)-one

2-(benzyloxy)-3-methoxy-6-nitrobenzaldehyde

6-amino-2-benzyloxy-3-methoxybenzoic acid

2-benzyloxy-3-methoxy-6-nitrobenzoic acid

Downstream raw materials:

5-(benzyloxy)-6-methoxy-4-<<2-<(n-propylcarbonyl)oxy>ethyl>amino>quinazoline

6,7-Bis-aziridin-1-yl-4-(3-dimethylamino-propylamino)-quinazoline-5,8-dione

4-(3-Dimethylamino-propylamino)-6-methoxy-quinazoline-5,8-dione

5-(benzyloxy)-4-<(8-hydroxy-3,6-dioxaoctyl)oxy>-6-methoxyquinazoline

Refernces