Technology Process of N-{3-[5-(2-chloropyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide
There total 11 articles about N-{3-[5-(2-chloropyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,5-difluoro-N-{2-fluoro-3-[(2-chloropyridin-4-yl)acetyl]phenyl}-N-(methoxymethyl)benzenesulfonamide;
With
pyridinium perbromide hydrobromide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.833333h;
Inert atmosphere;
tetrahydro-2H-pyran-4-carbothioamide;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 2h;
With
sodium hydrogencarbonate;
In
water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C
3.1: isopropylmagnesium chloride / tetrahydrofuran / 0 - 20 °C
3.2: 0.33 h / 0 °C
4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane; tetrahydrofuran / 0 - 20 °C / Inert atmosphere
4.2: 0 °C
5.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1.08 h / -78 °C / Inert atmosphere
5.2: 1.17 h / -78 - 0 °C
6.1: pyridinium perbromide hydrobromide / N,N-dimethyl-formamide / 0.83 h / 20 °C / Inert atmosphere
6.2: 2 h / 60 °C
With
4-methyl-morpholine; pyridine; dmap; n-butyllithium; pyridinium perbromide hydrobromide; isopropylmagnesium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ammonia / water / 18 h / 20 °C
2.1: Lawessons reagent / tetrahydrofuran / 4 h / Reflux
3.1: pyridinium perbromide hydrobromide / N,N-dimethyl-formamide / 0.83 h / 20 °C / Inert atmosphere
3.2: 2 h / 60 °C
With
Lawessons reagent; pyridinium perbromide hydrobromide; ammonia;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
