5-Chloro-N,2-dihydroxybenzamide

Base Information

• Chemical Name: 5-Chloro-N,2-dihydroxybenzamide
• CAS No.: 37551-43-2
• Molecular Formula: C7H6 Cl N O3
• Molecular Weight: 187.583
• Hs Code.: 2924299090
• European Community (EC) Number: 253-550-0
• DSSTox Substance ID: DTXSID4068036
• Nikkaji Number: J261.197J
• Wikidata: Q81994735
• Mol file: 37551-43-2.mol

Synonyms:5-Chloro-N,2-dihydroxybenzamide;37551-43-2;Benzamide, 5-chloro-N,2-dihydroxy-;EINECS 253-550-0;Oprea1_051003;5-chlorosalicylhydroxamic acid;5-Chloro-N,2-dihydrobenzamide;5-chloro-salicylhydroxamic acid;SCHEMBL5506621;DTXSID4068036;MFCD00203857;AKOS000178801;DS-15874;CS-0061689;FT-0620324;W17197;A823752

Chemical Property of 5-Chloro-N,2-dihydroxybenzamide

Chemical Property:

• Melting Point: 208℃
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 69.56000
• Density: 1.548g/cm³
• LogP: 1.55550
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 187.0036207
• Heavy Atom Count: 12
• Complexity: 176

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Chloro-N,2-dihydroxybenzamide 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)C(=O)NO)O

Technology Process of 5-Chloro-N,2-dihydroxybenzamide

There total 3 articles about 5-Chloro-N,2-dihydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

5-chloro-2-hydroxybenzoic acid (321-14-2) → N-(5-chlorosalicyl) hydroxamic acid (37551-43-2)

Guidance literature:

With sodium hydroxide; sulfuric acid; hydroxylamine sulfate; In methanol; water;

Reference yield:

methyl 5-chloro-2-hydroxybenzoate (4068-78-4) → N-(5-chlorosalicyl) hydroxamic acid (37551-43-2)

Guidance literature:

With ethanol; hydroxylamine;

Reference yield:

→ N-(5-chlorosalicyl) hydroxamic acid (37551-43-2)

Guidance literature:

B1: Methylester, NH2OH;

upstream raw materials:

methyl 5-chloro-2-hydroxybenzoate

5-chloro-2-hydroxybenzoic acid

Downstream raw materials:

6-chloro-2-(2-chloro-ethyl)-3-hydroxy-2,3-dihydro-benzo[e][1,3]oxazin-4-one

7-chloro-2c-methyl-(3ar)-3,3a-dihydro-2H-benzo[e]isoxazolo[3,2-b][1,3]oxazin-9-one

7-chloro-2t-methyl-(3ar)-3,3a-dihydro-2H-benzo[e]isoxazolo[3,2-b][1,3]oxazin-9-one

7-chloro-3,3a-dihydro-2H-benzo[e]isoxazolo[3,2-b][1,3]oxazin-9-one

Refernces

• 1、 Yevich, Joseph P.,New, James S.,Smith, David W.,Lobeck, Walter G.,Catt, John D.,et al.. "Synthesis and Biological Evaluation of 1-(1,2-Benzisothiazol-3-yl)- and (1,2-Benzisoxazol-3-yl)piperazine Derivatives as Potential Antipsychotic Agents". . p. 359 - 369. Retrieved 2007/10/02.
• 2、 -. "Chemical process for preparation of 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)-benzoxazin-9-one". . . Retrieved 2008/06/13.