Elacridar

Base Information

• Chemical Name: Elacridar
• CAS No.: 143664-11-3
• Molecular Formula: C34H33N3O5
• Molecular Weight: 563.64
• Hs Code.: 29334900
• European Community (EC) Number: 878-621-9
• UNII: N488540F94
• DSSTox Substance ID: DTXSID90162489
• Nikkaji Number: J548.787K
• Wikidata: Q27095554
• NCI Thesaurus Code: C73318
• Pharos Ligand ID: QHLT4B2TZS8Q
• Metabolomics Workbench ID: 149311
• ChEMBL ID: CHEMBL396298
• Mol file: 143664-11-3.mol

Synonyms:Elacridar;GF 120918;GF-120918;GF120918;GF120918A;GG918;N-(4-(2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl)phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide

Chemical Property of Elacridar

Chemical Property:

• Appearance/Colour: Yellow Solid
• Vapor Pressure: 1.57E-19mmHg at 25°C
• Melting Point: 216-218 °C
• Refractive Index: 1.644
• Boiling Point: 701.6 °C at 760 mmHg
• PKA: 12.58±0.70(Predicted)
• Flash Point: 378.1 °C
• PSA: 92.89000
• Density: 1.264 g/cm³
• LogP: 5.57110
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO: soluble2mg/mL (clear solution, warmed)
• XLogP3: 5.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 563.24202116
• Heavy Atom Count: 42
• Complexity: 925

Purity/Quality:

98%,99%, ^*data from raw suppliers

Elacridar ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC
• Uses: A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport. Elacridar has been used:as a chemical to decipher the link between autophagy and the mechanism of resistance to sunitinibas an ATP-binding cassette sub-family B member 1 inhibitor to study its effects on the NSC23766 cytotoxicityto treat rhodamine 123 (Rh123) labeled cells to set sorting gates in fluorescence-activated cell sorting (FACS)