N,N'-Bis(salicylidene)ethylenediaminocobalt(II) hydrate

Base Information

• Chemical Name: N,N'-Bis(salicylidene)ethylenediaminocobalt(II) hydrate
• CAS No.: 14167-18-1
• Molecular Formula: C₁₆H₁₄N₂O₂*Co
• Molecular Weight: 325.293
• Hs Code.: 29349990
• European Community (EC) Number: 238-012-5
• Wikipedia: Salcomine
• Mol file: 14167-18-1.mol

Synonyms:N,N-ethylenebis(salicylideneiminato)cobalt(II);salcomine

Chemical Property of N,N'-Bis(salicylidene)ethylenediaminocobalt(II) hydrate

Chemical Property:

• Appearance/Colour: black crystalline powder
• Melting Point: >300 °C
• Boiling Point: 498.2ºC at 760 mmHg
• PSA: 43.18000
• LogP: 1.78200
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Insoluble in water. Soluble in benzene, chloroform, and pyridine.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 327.054371
• Heavy Atom Count: 21
• Complexity: 304

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N''-Bis(salicylidene)ethylenediaminecobalt(II) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Metals -> Organic Compounds, Metal Salts
• Canonical SMILES: C1=CC=C(C(=C1)C=NCCN=CC2=CC=CC=C2O)O.[Co]
• Uses: Salcomine catalyzes the oxidation of 2,6-disubstituted phenols by dioxygen. Experimental inhibitor of human cytμloviris proteinase activity. Metal complex dyes used as redox catalysts.

Technology Process of N,N'-Bis(salicylidene)ethylenediaminocobalt(II) hydrate

There total 64 articles about N,N'-Bis(salicylidene)ethylenediaminocobalt(II) hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(cis-4,4,7,7,8,9-hexahydro-1,3-dioxoisobenzofuran-6-yl)(aquo)(N,N'-ethylenebis(salicylideneaminato))cobalt(III) → salcomine (14167-18-1,1160066-30-7,1094215-76-5)

Guidance literature:

byproducts: cis-1,2,3,6-tetrahydrophtalic acid; drying by exposure to open atmosphere, heating (130°C, 0.1 torr, 30 min); acid sublimation, product collection; identified by IR spectroscopy;

Reference yield: 96.0%

[(aqua)(Co(III))(sal2en)]hydroxide (21710-17-8) → salcomine (14167-18-1,1160066-30-7,1094215-76-5)

Guidance literature:

In methanol; stirring (25°C, 1 h); pptn. on Et2O addn., filtration, drying (100°C, 18 h); identifiedby IR spectroscopy;

Reference yield: 95.0%

[1-(1-oxoethyl)-3-cyclohexen-4-yl](aquo)(N,N'-ethylenebis(salicylideneaminato))cobalt(III) (187172-87-8) → salcomine (14167-18-1,1160066-30-7,1094215-76-5)

Guidance literature:

byproducts: 1-acetyl-3-cyclohexene; drying by exposure to open atmosphere, heating (130°C, 0.1 torr, 30 min) with cold finger with dry ice; acid sublimation, product collection; identified by IR spectroscopy;

upstream raw materials:

cobalt(II) acetate

salicylaldehyde

ethylenediamine

N,N'-ethylenebis(salicylideneimine)

Downstream raw materials:

bis(salicylidene)-ethylenediamine-cobalt(II) * chloroform

bis(salicylidene)-ethylenediamine-cobalt(II) * oxygen

carbon dioxide

Refernces

• 1、 Tripathi, Deependra,Singh, Raj K.. "Oxidative Desulfurization of Dibenzothiophene Using Cobalt (II) Complexes with Substituted Salen-Type Ligands as Catalysts in Model Fuel Oil". . p. 713 - 719. Retrieved 2020/08/06.
• 2、 Gowdhami, Balakrishnan,Ambika, Subramanian,Karthiyayini, Balakrishnan,Ramya, Venkatesan,Kadalmani, Balamuthu,Vimala,Akbarsha, Mohammad A.. "Potential application of two cobalt (III) Schiff base complexes in cancer chemotherapy: Leads from a study using breast and lung cancer cells". . . Retrieved 2021/07/12.