N-isopropylphenylketenimine

Base Information

• Chemical Name: N-isopropylphenylketenimine
• CAS No.: 34621-17-5
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 159.231
• Mol file: 34621-17-5.mol

Synonyms:N-isopropylphenylketenimine

Chemical Property of N-isopropylphenylketenimine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-isopropylphenylketenimine

There total 5 articles about N-isopropylphenylketenimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-isopropyl-2-phenylacetamide (5215-54-3) → N-isopropylphenylketenimine (34621-17-5)

Guidance literature:

N-isopropyl-2-phenylacetamide; With phosphorus pentachloride; In benzene; for 1h; Heating;

With triethylamine; In diethyl ether; for 6h; Heating;

DOI:10.1016/j.tet.2005.09.119

Reference yield:

N-isopropylphenylacetimidoyl chloride (74157-83-8) → N-isopropylphenylketenimine (34621-17-5)

Guidance literature:

With triethylamine; In benzene; for 6h; Heating;

DOI:10.1039/P29800000579

Reference yield:

phenylacetic acid (103-82-2) → N-isopropylphenylketenimine (34621-17-5)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / benzene

2: triethylamine / diethyl ether / 5 h / Ambient temperature

3: PCl₅ / benzene / 1 h / Heating

4: NEt₃ / benzene / 6 h / Heating

With thionyl chloride; phosphorus pentachloride; triethylamine; In diethyl ether; benzene;

DOI:10.1039/P29800000579

upstream raw materials:

N-isopropylphenylacetimidoyl chloride

N-isopropyl-2-phenylacetamide

phenylacetic acid

phenylacetyl chloride

Downstream raw materials:

N-acetyl-N-isopropyl-2-phenylacetamide

N-isopropyl-2-phenylacetamide

Refernces

• 1、 Hegarty, Anthony F.,Kelly, John G.,Relihan, Colette M.. "Formation of hemiaminals by N-protonation of ketenimines (etheneimines) sterically hindered at carbon". . p. 1175 - 1181. Retrieved 2007/10/03.