Difenidol hydrochloride

Base Information

• Chemical Name: Difenidol hydrochloride
• CAS No.: 3254-89-5
• Molecular Formula: C21H27NO^.HCl
• Molecular Weight: 345.912
• Hs Code.: 2933399090
• European Community (EC) Number: 221-850-0
• NSC Number: 23012
• UNII: DG355XWQ4T
• DSSTox Substance ID: DTXSID10186248
• Wikidata: Q27276383
• NCI Thesaurus Code: C65422
• ChEMBL ID: CHEMBL1529
• Mol file: 3254-89-5.mol

Synonyms:Ansmin;Cefadol;Celmidol;Difenidolin;Maniol;Mecalmin;Pineroro;SKF 478A;Satanolon;Tenesdol;Vontrol;Wansar;

Chemical Property of Difenidol hydrochloride

Chemical Property:

• Appearance/Colour: crystals, soluble in methanol, water
• Vapor Pressure: 9.19E-10mmHg at 25°C
• Melting Point: 212-214°
• Boiling Point: 473.3 °C at 760 mmHg
• Flash Point: 233.5 °C
• PSA: 23.47000
• LogP: 4.12650
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly, Sonicated), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 345.1859422
• Heavy Atom Count: 24
• Complexity: 307

Purity/Quality:

99% ^*data from raw suppliers

DiphenidolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl
• Uses: Diphenidol is an muscarinic antagonist is an antivertigo agent. Diphenidol displays heart arrhythmia inhibition and parasympatholytic activity.

Technology Process of Difenidol hydrochloride

There total 1 articles about Difenidol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.14%

N-(3-chloropropyl)-piperidine (1458-63-5) + benzophenone (119-61-9) → diphenidol hydrochloride (3254-89-5)

Guidance literature:

N-(3-chloropropyl)-piperidine; With ethyl bromide; iodine; magnesium; In tetrahydrofuran; at 70 ℃; for 0.5h; Inert atmosphere;

benzophenone; In tetrahydrofuran; at 70 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In water; acetone; at 5 - 50 ℃; pH=6; Temperature; Solvent;

upstream raw materials:

N-(3-chloropropyl)-piperidine

benzophenone

Refernces

• 1、 -. "Preparation method of difenidol hydrochloride". Paragraph 0039; 0040. . Retrieved 2017/07/21.