N-tert-butyl-[2-(4'-methoxy)phenyl]ethylamine

Base Information

• Chemical Name: N-tert-butyl-[2-(4'-methoxy)phenyl]ethylamine
• CAS No.: 151813-51-3
• Molecular Formula: C₁₃H₂₁NO
• Molecular Weight: 207.316
• Mol file: 151813-51-3.mol

Synonyms:N-tert-butyl-[2-(4'-methoxy)phenyl]ethylamine

Chemical Property of N-tert-butyl-[2-(4'-methoxy)phenyl]ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butyl-[2-(4'-methoxy)phenyl]ethylamine

There total 7 articles about N-tert-butyl-[2-(4'-methoxy)phenyl]ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(p-methoxyphenyl)ethyl toluene-p-sulphonate (5107-52-8) + tert-butylamine (75-64-9) → N-tert-butyl-[2-(4'-methoxy)phenyl]ethylamine (151813-51-3)

Guidance literature:

With sodium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 20 - 65 ℃; for 6h;

DOI:10.1021/ja00072a021

Reference yield: 61.0%

1,3-dioxoisoindolin-2-yl 3-(N-tert-butyl-4-methoxybenzamido)propanoate → N-tert-butyl-[2-(4'-methoxy)phenyl]ethylamine (151813-51-3)

Guidance literature:

With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; In water; acetonitrile; at 20 ℃; for 16h; Reagent/catalyst; Solvent; Schlenk technique; Sealed tube; Irradiation;

DOI:10.1021/acs.joc.8b01538

Reference yield: 28.0%

tert-butylamine (75-64-9) + 4-methoxyphenylacetylen (768-60-5) → N-tert-butyl-[2-(4'-methoxy)phenyl]ethylamine (151813-51-3)

Guidance literature:

tert-butylamine; 4-methoxyphenylacetylen; tetrakis(dimethylamido)titanium(IV); In toluene; at 105 ℃; for 24h;

With sodium cyanoborohydride; zinc(II) chloride; In methanol; toluene; at 25 ℃; for 20h; Further stages.;

DOI:10.1055/s-2007-986651

upstream raw materials:

2-(p-methoxyphenyl)ethyl toluene-p-sulphonate

tert-butylamine

4-methoxyphenylacetylen

4-Methoxyphenylacetaldehyde

Downstream raw materials:

N-(tert-butyl)-2-diazo-N-(4-methoxyphenethyl)acetamide

N-tert-butyl-4-p-anisyl-2-pyrrolidone

N-tert-butyl-N-(2-p-anisylethyl)acetoacetamide

Refernces

• 1、 Nakagawa, Yoko,Chanthamath, Soda,Liang, Yumeng,Shibatomi, Kazutaka,Iwasa, Seiji. "Regio- and Enantioselective Intramolecular Amide Carbene Insertion into Primary C-H Bonds Using Ru(II)-Pheox Catalyst". . p. 2607 - 2618. Retrieved 2019/02/26.
• 2、 Zhang, Zhe,Leitch, David C.,Lu, Man,Patrick, Brian O.,Schafer, Laurel L.. "An easy-to-use, regioselective, and robust bis(amidate) titanium hydroamination precatalyst: Mechanistic and synthetic investigations toward the preparation of tetrahydroisoquinolines and benzoquinolizine alkaloids". . p. 2012 - 2022. Retrieved 2008/02/04.