PCF 39

Base Information

• Chemical Name: PCF 39
• CAS No.: 104317-64-8
• Molecular Formula: C₁₇H₂₆N₈O₅
• Molecular Weight: 422.444
• Mol file: 104317-64-8.mol

Synonyms:PCF 39; ST789

Chemical Property of PCF 39

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 204.85000
• Density: 1.54g/cm³
• LogP: 1.54020

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PCF 39

There total 8 articles about PCF 39 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N9-(ω-hydroxy-n-amyl)hypoxanthine (7292-60-6) → N2-(5-(hypoxanthin-9-yl)pentyloxycarbonyl)-L-arginine (104317-64-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; toluene / 8 h

2: aq. NaHCO₃ / tetrahydrofuran

With sodium hydrogencarbonate; In tetrahydrofuran; toluene;

DOI:10.1021/jm960844m

Reference yield:

1 ,5-pentanediol (111-29-5) → N2-(5-(hypoxanthin-9-yl)pentyloxycarbonyl)-L-arginine (104317-64-8)

Guidance literature:

Multi-step reaction with 5 steps

1: NaH / CH₂Cl₂ / 2.25 h / 0 - 20 °C

2: 1.) PPh₃, DEAD / 1.) THF, 10 min, 2.) THF, RT, overnight

3: Bu₄NF / tetrahydrofuran

4: tetrahydrofuran; toluene / 8 h

5: aq. NaHCO₃ / tetrahydrofuran

With tetrabutyl ammonium fluoride; sodium hydride; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/jm960844m

Reference yield:

5-(tert-butyldiphenylsilyloxy)pentan-1-ol (121671-76-9) → N2-(5-(hypoxanthin-9-yl)pentyloxycarbonyl)-L-arginine (104317-64-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) PPh₃, DEAD / 1.) THF, 10 min, 2.) THF, RT, overnight

2: Bu₄NF / tetrahydrofuran

3: tetrahydrofuran; toluene / 8 h

4: aq. NaHCO₃ / tetrahydrofuran

With tetrabutyl ammonium fluoride; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;

DOI:10.1021/jm960844m

upstream raw materials:

L-arginine

C₁₁H₁₃ClN₄O₃*ClH

C₁₁H₁₃ClN₄O₃

1 ,5-pentanediol

Refernces

• 1、 Stradi,Rossi,Perezzani,Migliorati,Riccardi,Cornaglia-Ferraris. "Synthetic biological response modifiers; part 1. Synthesis and immunomodulatory properties of some N2-(ω-(hypoxanthin-9-yl)alkoxycarbonyl)-L-arginines". . p. 39 - 47. Retrieved 2007/10/02.