4-Cyanopiperidine

Base Information

• Chemical Name: 4-Cyanopiperidine
• CAS No.: 4395-98-6
• Molecular Formula: C6H10N2
• Molecular Weight: 110.159
• Hs Code.: 29333990
• Mol file: 4395-98-6.mol

Synonyms:Isonipecotonitrile(6CI,8CI);4-Piperidinecarbonitrile;piperidine-4-carbonitrile;

Chemical Property of 4-Cyanopiperidine

Chemical Property:

• Appearance/Colour: Yellowish-orangish oil
• Vapor Pressure: 0.082mmHg at 25°C
• Melting Point: 0°C
• Refractive Index: 1.4755
• Boiling Point: 226.4 °C at 760 mmHg
• PKA: 9.26±0.10(Predicted)
• Flash Point: 90.7 °C
• PSA: 35.82000
• Density: 0.98 g/cm³
• LogP: 0.83838
• Storage Temp.: 2-8°C
• Solubility.: Soluble in chloroform.

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Cyanopiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-41-22
• Safety Statements: 26-36/37/39-36-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Cyanopiperidine is used as an intermediate for the preparation of pharmaceutical substances like antidepressants and anti-inflammatory. It is used as a precursor for the synthesis of piperidine derivatives.

Technology Process of 4-Cyanopiperidine

There total 7 articles about 4-Cyanopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-tert-butoxycarbonyl-4-cyanopiperidine (91419-52-2) → 4-cyanopiperidine (4395-98-6)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.5h;

Reference yield: 86.0%

4-carboxamidopiperidine (39546-32-2) → 4-cyanopiperidine (4395-98-6)

Guidance literature:

With thionyl chloride; for 3h; Heating;

DOI:10.1021/jm0309349

Reference yield:

4-carboxamidopiperidine (39546-32-2) + 4-cyano-1-trifluoroacetylpiperidine (77940-79-5) → 4-cyanopiperidine (4395-98-6)

Guidance literature:

With potassium carbonate; trifluoroacetic anhydride; In methanol; water; benzene;

upstream raw materials:

4-carboxamidopiperidine

1-tert-butoxycarbonyl-4-cyanopiperidine

4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester

4-cyano-1-trifluoroacetylpiperidine

Downstream raw materials:

piperidine-4-carbothioamide

1-<2-bis(4-fluorophenyl)methoxyethyl>-4-cyanopiperidine

1-tert-butoxycarbonyl-4-cyanopiperidine

1-(benzoyl)piperidine-4-carbonitrile

Refernces

• 1、 -. "COSMETIC COMPOSITIONS WITH TRICYCLODECANE AMIDES". Paragraph 0128-0129. . Retrieved 2016/02/26.
• 2、 -. "SULFONAMIDE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG". Page/Page column 102. . Retrieved 2014/01/17.