Benzyl N-(2-hydroxyethyl)carbamate

Base Information

• Chemical Name: Benzyl N-(2-hydroxyethyl)carbamate
• CAS No.: 77987-49-6
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Hs Code.: 29221985
• European Community (EC) Number: 629-174-1
• NSC Number: 132101
• DSSTox Substance ID: DTXSID60299690
• Nikkaji Number: J534.096I
• Wikidata: Q82042204
• ChEMBL ID: CHEMBL2259791
• Mol file: 77987-49-6.mol

Synonyms:77987-49-6;Benzyl N-(2-hydroxyethyl)carbamate;Z-Glycinol;Benzyl (2-hydroxyethyl)carbamate;N-Z-Ethanolamine;2-(Z-Amino)ethanol;benzyl 2-hydroxyethylcarbamate;2-(Cbz-amino)ethanol;N-(benzyloxycarbonyl)ethanolamine;2-(Carbobenzoxyamino)-1-ethanol;N-(2-Hydroxyethyl)carbamic Acid Benzyl Ester;Carbamic acid, (2-hydroxyethyl)-, phenylmethyl ester;MFCD00191060;2-(Cbz-amino)-1-ethanol;benzyl(2-hydroxyethyl)carbamate;N-Cbz-ethanolamine;Z-Gly-ol;NSC132101;N-CBZ-2-aminoethanol;N-CBZ-GLYCINOL;N-(2-hydroxyethyl)(phenylmethoxy)carboxamide;N-Z-Ethanolamine, 98%;2-benzyloxycarbonylaminoethanol;SCHEMBL375858;N-benzyloxycarbonyl-ethanolamine;benzyl N-2-hydroxyethylcarbamate;CHEMBL2259791;DTXSID60299690;SAGINAGERRNGGV-UHFFFAOYSA-N;N-Benzyloxycarbonyl-2-aminoethanol;2-(N-benzyloxycarbonylamino)ethanol;benzyl n-(2-hydroxyethyl)-carbamate;AKOS004908091;benzyl N-(2-hydroxy-ethyl)-carbamate;CS-W004853;NSC-132101;AC-31982;BP-23196;DS-16794;SY051387;(2-hydroxyethyl)carbamic acid benzyl ester;(2-hydroxyethyl)-carbamic acid benzyl ester;FT-0653374;H0793;EN300-104526;A839306;AE-562/43460398;Z31725823

Chemical Property of Benzyl N-(2-hydroxyethyl)carbamate

Chemical Property:

• Vapor Pressure: 3.28E-06mmHg at 25°C
• Melting Point: 50-60 °C
• Refractive Index: 1.542
• Boiling Point: 372.5 °C at 760 mmHg
• PKA: 11.80±0.46(Predicted)
• Flash Point: 179.1 °C
• PSA: 58.56000
• Density: 1.182 g/cm³
• LogP: 1.29600
• Storage Temp.: Store at 0-5°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 195.08954328
• Heavy Atom Count: 14
• Complexity: 167

Purity/Quality:

98%,99%, ^*data from raw suppliers

Z-Glycinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCCO

Technology Process of Benzyl N-(2-hydroxyethyl)carbamate

There total 16 articles about Benzyl N-(2-hydroxyethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanolamine (141-43-5) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 2-hydroxyethylcarbamate (77987-49-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield: 100.0%

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + ethanolamine (141-43-5) → benzyl 2-hydroxyethylcarbamate (77987-49-6)

Guidance literature:

With sodium carbonate; In water; acetone; at 20 ℃; for 4h;

Reference yield: 96.0%

acetic acid 2-benzyloxycarbonylamino-ethyl ester → benzyl 2-hydroxyethylcarbamate (77987-49-6)

Guidance literature:

With methanol; potassium permanganate; trimethylsulphonium iodide; at 25 ℃; under 760.051 Torr; chemoselective reaction;

DOI:10.1039/d1ra03209g

upstream raw materials:

ethanolamine

benzyl chloroformate

Z-DL-serine

C₁₃H₁₅NO₆

Downstream raw materials:

2-oxo-oxazolidine-3-carboxylic acid benzyl ester

(2-carbamoyloxy-ethyl)-carbamic acid benzyl ester

bis(2-aminoethanol) hydrogen phosphate

1-oxa-4-aza-spiro[4.5]decane-4-carboxylic acid benzyl ester

Refernces

• 1、 Bolte, Michael,Grimmer, Jennifer,Kelm, Harald,Kramer, Philipp,Krieg, Sara-Cathrin,Manolikakes, Georg. "Oxyenamides as Versatile Building Blocks for a Highly Stereoselective One-Pot Synthesis of the 1,3-Diamino-2-ol-Scaffold Containing Three Continuous Stereocenters". supporting information. p. 23667 - 23671. Retrieved 2021/09/30.
• 2、 -. "PROCESS OF PREPARING ARACHIDONOYLETHANOLAMINE ANALOGUES". Page/Page column 25. . Retrieved 2021/05/29.