2-Amino-6-nitrobenzaldehyde

Base Information

• Chemical Name: 2-Amino-6-nitrobenzaldehyde
• CAS No.: 130133-53-8
• Molecular Formula: C₇H₆N₂O₃
• Molecular Weight: 166.136
• Hs Code.: 2922390090
• European Community (EC) Number: 823-541-1
• Mol file: 130133-53-8.mol

Synonyms:2-amino-6-nitrobenzaldehyde;130133-53-8;2-Amino-6-nitro-benzaldehyde;Benzaldehyde,2-amino-6-nitro-;SCHEMBL9141067;Benzaldehyde, 2-amino-6-nitro-;MFCD18389895;AKOS027364561;AS-47726;F15865;EN300-7834193;Z1255418982

Chemical Property of 2-Amino-6-nitrobenzaldehyde

Chemical Property:

• Boiling Point: 378.7±32.0 °C(Predicted)
• PKA: -1.42±0.10(Predicted)
• Density: 1.441±0.06 g/cm3(Predicted)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 166.03784206
• Heavy Atom Count: 12
• Complexity: 190

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-6-nitro-benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)[N+](=O)[O-])C=O)N

Technology Process of 2-Amino-6-nitrobenzaldehyde

There total 7 articles about 2-Amino-6-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-amino-6-nitrobenzaldehyde ethylene acetal (151585-78-3) → 2-amino-6-nitrobenzaldehyde (130133-53-8)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; for 1h;

DOI:10.1021/jm00070a013

Reference yield: 88.0%

2-amino-6-nitrobenzyl alcohol (98451-51-5) → 2-amino-6-nitrobenzaldehyde (130133-53-8)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.08.004

Reference yield:

2,6-dinitrotoluene (606-20-2) → meta-dinitrobenzene (99-65-0) + 6-nitroanthranilic acid (50573-74-5) + ortho-cresol (95-48-7,77504-84-8) + 2-amino-6-nitrobenzaldehyde (130133-53-8) + 5-nitro-2,1-benzisoxazole (188860-13-1)

Guidance literature:

In benzene; at 340 ℃; Product distribution; Kinetics; Rate constant; in sealed tube; other solvent (neat);

DOI:10.1021/j100023a043

upstream raw materials:

2-amino-6-nitrobenzaldehyde ethylene acetal

2,6-dinitrotoluene

2,6-dinitrobenzaldehyde

2,6-dinitrobenzaldehyde ethylene acetal

Downstream raw materials:

9-amino-(20RS)-camptothecin

camptothecin

10-hydroxycamptothecin

9-amino-20(S)-camptothecin

Refernces

• 1、 Oxley, Jimmie C.,Smith, James L.,Ye, Hong,McKenney, Robert L.,Bolduc, Paul R.. "Thermal Stability Studies on a Homologous Series of Nitroarenes". . p. 9593 - 9602. Retrieved 2007/10/02.