adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline

Base Information

• Chemical Name: adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline
• CAS No.: 391219-37-7
• Molecular Formula: C₁₉H₂₄ClNO
• Molecular Weight: 317.859
• Mol file: 391219-37-7.mol

Synonyms:adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline

Chemical Property of adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline

There total 2 articles about adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

rimantadine (13392-28-4,117857-51-9,117857-52-0,129277-01-6) + 5-chlorosalicyclaldehyde (635-93-8) → adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline (391219-37-7)

Guidance literature:

In ethanol; at 60 ℃; for 1h;

DOI:10.1080/00958972.2014.885509

Reference yield:

rimantadine hydrochloride (1501-84-4,33122-80-4,33122-81-5,33298-76-9) → adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline (391219-37-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 1 h

2: ethanol / 1 h / 60 °C

With potassium hydroxide; In ethanol;

DOI:10.1080/00958972.2014.885509

Reference yield: 75.0%

trans-μ-dichlorobis[(2,6-diisopropyl-N-(4-methoxybenzyliden-2-ido)aniline)palladium(II)] (1334680-68-0) + adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline (391219-37-7) → C39H47ClN2O2Pd

Guidance literature:

adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline; With sodium hydroxide; In methanol; at 20 ℃; for 5h;

trans-μ-dichlorobis[(2,6-diisopropyl-N-(4-methoxybenzyliden-2-ido)aniline)palladium(II)]; In methanol; for 16h;

DOI:10.1016/j.jorganchem.2015.04.050

upstream raw materials:

rimantadine hydrochloride

rimantadine

5-chlorosalicyclaldehyde

Refernces