N-Phth-Trp-Phe-OMe

Base Information

• Chemical Name: N-Phth-Trp-Phe-OMe
• CAS No.: 1194629-99-6
• Molecular Formula: C₂₉H₂₅N₃O₅
• Molecular Weight: 495.535
• Mol file: 1194629-99-6.mol

Synonyms:N-Phth-Trp-Phe-OMe

Chemical Property of N-Phth-Trp-Phe-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Phth-Trp-Phe-OMe

There total 2 articles about N-Phth-Trp-Phe-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) + N-phthalimide-L-tryptophan (32675-71-1,48208-26-0,62361-30-2) → N-Phth-Trp-Phe-OMe (1194629-99-6)

Guidance literature:

With 2,6-dimethylpyridine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

DOI:10.1021/ol403281t

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) + N-phthalimide-L-tryptophan (32675-71-1,48208-26-0,62361-30-2) → N-Phth-Trp-Phe-OMe (1194629-99-6)

Guidance literature:

With benzotriazol-1-ol; triethylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1002/anie.200902761

Reference yield: 79.0%

(Z)-2-Butene (590-18-1) + N-Phth-Trp-Phe-OMe (1194629-99-6) → C33H31N3O5 (1194629-97-4)

Guidance literature:

With copper diacetate; palladium diacetate; silver trifluoroacetate; In acetonitrile; at 35 ℃; for 24h; chemoselective reaction;

DOI:10.1002/anie.200902761

upstream raw materials:

methyl (2S)-2-amino-3-phenylpropanoate

N-phthalimide-L-tryptophan

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

Downstream raw materials:

C₃₃H₃₁N₃O₅

C₃₄H₃₃N₃O₅

C₃₄H₃₃N₃O₅

C₃₅H₂₉IN₄O₅

Refernces

• 1、 Luzung, Michael R.,Lewis, Chad A.,Baran, Phil S.. "Direct, chemoselective N-teri-prenylation of indoles by C-H functionalization". supporting information; experimental part. p. 7025 - 7029. Retrieved 2009/12/26.